Differentiating fibroadenoma and ductal carcinoma in situ from normal breast tissue by multiphoton microscopy

Yuting Nie; Yan Wu; Yuane Lian; Fangmeng Fu; Chuan Wang; Jianxin Chen

doi:10.1117/12.2068512

17 September 2014 Differentiating fibroadenoma and ductal carcinoma in situ from normal breast tissue by multiphoton microscopy

Yuting Nie, Yan Wu, Yuane Lian, Fangmeng Fu, Chuan Wang, Jianxin Chen

Author Affiliations +

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 92301N (2014) https://doi.org/10.1117/12.2068512
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

Fibroadenoma (FA) is the most common benign tumor of the female breast and several studies have reported that women with it have increased risk of breast cancer. While the ductal carcinoma in situ (DCIS) is a very early form of breast cancer. Thus, early detections of FA and DCIS are critical for improving breast tumor outcome and survival. In this paper, we use multiphoton microscopy (MPM) to obtain the high-contrast images of fresh, unfixed, unstained human breast specimens (normal breast tissue, FA and DCIS). Our results show that MPM has the ability to identify the characteristics of FA and DCIS including changes of duct architecture and collagen morphology. These results are consistent with the histological results. With the advancement of MPM, the technique has potential ability to serve as a real-time noninvasive imaging tool for early detection of breast tumor.

Citation Download Citation

Yuting Nie, Yan Wu, Yuane Lian, Fangmeng Fu, Chuan Wang, and Jianxin Chen "Differentiating fibroadenoma and ductal carcinoma in situ from normal breast tissue by multiphoton microscopy", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92301N (17 September 2014); https://doi.org/10.1117/12.2068512

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available