Multifunctional magneto-plasmonic nanotransducers for advanced theranostics: synthesis, modeling and experiment

Masoud Masoumi; Ya Wang; Mingzhao Liu; Mahder Tewolde; Jon Longtin

doi:10.1117/12.2187102

2 April 2015 Multifunctional magneto-plasmonic nanotransducers for advanced theranostics: synthesis, modeling and experiment

Masoud Masoumi, Ya Wang, Mingzhao Liu, Mahder Tewolde, Jon Longtin

Author Affiliations +

Proceedings Volume 9431, Active and Passive Smart Structures and Integrated Systems 2015; 94311X (2015) https://doi.org/10.1117/12.2187102
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2015, San Diego, California, United States

Abstract

In this work, nano-transducers with a superparamagnetic iron oxide (SPIO) core have been synthesized by preparation of precursor gold nanoseeds loaded on SPIO-embedded silica to form a gold nanoshell. The goal is for such nanotansducers to be used in theranostics to detect brain tumors by using MRI imaging and then assist in their treatment by using photothermal ablation. The iron oxide core provides for the use of a magnetic-field to guide the particles to the target (tumor) site. The gold nanoshell can be then readily heated using incident light and/or an alternating magneticfield. After synthesis of nano-transducer samples, Transmission Electron Microscopy was employed to analyze the formation of each layer. Then UV spectroscopy experiments were conducted to examine the light absorbance of the synthesized samples. The UV-visible absorption spectra shows a clear surface plasmon resonance (SPR) band around 530 nm, verifying the presence of gold coating nanoshells. Finally photothermal experiments using a high-power laser beam with a wavelength of 527 nm were performed to heat the samples. It was found that the temperature reaches 45° C in 12 minutes.

Citation Download Citation

Masoud Masoumi, Ya Wang, Mingzhao Liu, Mahder Tewolde, and Jon Longtin "Multifunctional magneto-plasmonic nanotransducers for advanced theranostics: synthesis, modeling and experiment", Proc. SPIE 9431, Active and Passive Smart Structures and Integrated Systems 2015, 94311X (2 April 2015); https://doi.org/10.1117/12.2187102

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available