Multifunctional diagnostic, nanothermometer, and photothermal nano-devices

Kory Green; Janina Wirth M.D.; Megan O'Connor; Shuang Fang Lim

doi:10.1117/12.2188604

26 August 2015 Multifunctional diagnostic, nanothermometer, and photothermal nano-devices

Kory Green, Janina Wirth M.D., Megan O'Connor, Shuang Fang Lim

Proceedings Volume 9584, Ultrafast Nonlinear Imaging and Spectroscopy III; 95840D (2015) https://doi.org/10.1117/12.2188604
Event: SPIE Optical Engineering + Applications, 2015, San Diego, California, United States

Abstract

Photothermal treatment is a valuable part of cancer therapies, in which the temperature of the heated region must rise to at least 40-45°C for protein destruction to occur[1, 2]. In practice, heating temperature distributions are typically non-uniform, resulting in incomplete kill of cancer cells. Gold nanorods (AuNRs) show strong absorption in the near infrared which leads to a strong plasmonic photothermal (PPT) effect. However, basic scientific understanding of AuNR local temperature and heat transfer to local surroundings has not been investigated in detail. In our study, the near infrared (NIR) excited Upconversion nanoparticle (UCNP)-AuNR nanostructure combines the powerful diagnostic and thermal sensing capacity of UCNPs, with the known therapeutic property of AuNRs. We show enhanced upconverted emission with AuNRs coupling, improving diagnostic capacity of the construct. We demonstrate mapping of the temperature profile within tumor tissue phantom medium, at high spatial and temporal sensitivity.

Citation Download Citation

Kory Green, Janina Wirth M.D., Megan O'Connor, and Shuang Fang Lim "Multifunctional diagnostic, nanothermometer, and photothermal nano-devices", Proc. SPIE 9584, Ultrafast Nonlinear Imaging and Spectroscopy III, 95840D (26 August 2015); https://doi.org/10.1117/12.2188604

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