Lipid-anthropometric index optimization for insulin sensitivity estimation

J. Velásquez; S. Wong; L. Encalada; H. Herrera; E. Severeyn

doi:10.1117/12.2209328

22 December 2015 Lipid-anthropometric index optimization for insulin sensitivity estimation

J. Velásquez, S. Wong, L. Encalada, H. Herrera, E. Severeyn

Proceedings Volume 9681, 11th International Symposium on Medical Information Processing and Analysis; 96810R (2015) https://doi.org/10.1117/12.2209328
Event: 11th International Symposium on Medical Information Processing and Analysis (SIPAIM 2015), 2015, Cuenca, Ecuador

Abstract

Insulin sensitivity (IS) is the ability of cells to react due to insulin´s presence; when this ability is diminished, low insulin sensitivity or insulin resistance (IR) is considered. IR had been related to other metabolic disorders as metabolic syndrome (MS), obesity, dyslipidemia and diabetes. IS can be determined using direct or indirect methods. The indirect methods are less accurate and invasive than direct and they use glucose and insulin values from oral glucose tolerance test (OGTT). The accuracy is established by comparison using spearman rank correlation coefficient between direct and indirect method. This paper aims to propose a lipid-anthropometric index which offers acceptable correlation to insulin sensitivity index for different populations (DB1=MS subjects, DB2=sedentary without MS subjects and DB3=marathoners subjects) without to use OGTT glucose and insulin values. The proposed method is parametrically optimized through a random cross-validation, using the spearman rank correlation as comparator with CAUMO method. CAUMO is an indirect method designed from a simplification of the minimal model intravenous glucose tolerance test direct method (MINMOD-IGTT) and with acceptable correlation (0.89). The results show that the proposed optimized method got a better correlation with CAUMO in all populations compared to non-optimized. On the other hand, it was observed that the optimized method has better correlation with CAUMO in DB2 and DB3 groups than HOMA-IR method, which is the most widely used for diagnosing insulin resistance. The optimized propose method could detect incipient insulin resistance, when classify as insulin resistant subjects that present impaired postprandial insulin and glucose values.

Citation Download Citation

J. Velásquez, S. Wong, L. Encalada, H. Herrera, and E. Severeyn "Lipid-anthropometric index optimization for insulin sensitivity estimation", Proc. SPIE 9681, 11th International Symposium on Medical Information Processing and Analysis, 96810R (22 December 2015); https://doi.org/10.1117/12.2209328

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