Paper
29 March 2016 Measuring skin penetration by confocal Raman microscopy (CRM): correlation to results from conventional experiments
Dominique Lunter, Rolf Daniels
Author Affiliations +
Abstract
Confocal Raman microscopy has become an advancing technique in the characterization of drug transport into the skin. In this study the skin penetration of a local anesthetic from a semisolid preparation was investigated. Furthermore, the effect of the chemical enhancers propylene glycol and POE-23-lauryl ether on its penetration was investigated. The results show that confocal Raman microscopy may provide detailed information on the penetration of APIs into the skin and may elucidate their distribution within the skin with high resolution. The results of the CRM analysis are fully in line with those of conventional permeation and penetration experiments.
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Dominique Lunter and Rolf Daniels "Measuring skin penetration by confocal Raman microscopy (CRM): correlation to results from conventional experiments", Proc. SPIE 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, 978829 (29 March 2016); https://doi.org/10.1117/12.2214850
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Cited by 2 scholarly publications.
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KEYWORDS
Skin

Confocal microscopy

Raman spectroscopy

Microscopy

Diffusion

Statistical analysis

Ear

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