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7 March 2022 Optical scattering serves as a prognostic biomarker for immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model
Anup Tank, Cameron Vergato, David J. Waxman, Darren M. Roblyer
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Proceedings Volume PC11944, Multiscale Imaging and Spectroscopy III; PC1194407 (2022) https://doi.org/10.1117/12.2608388
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Spatial Frequency Domain Imaging (SFDI) can provide longitudinal label-free, wide field hemodynamic and scattering information of murine tumors. Here we present a longitudinal study utilizing SFDI to monitor a paired immune responsive-resistant model for up to 30 days of treatment. Mice receiving the immunomodulatory treatment had a large increase in the reduced optical scattering throughout treatment compared to the mice receiving an immune-blocking antibody. These results indicate that scattering is sensitive to the immune-mediated apoptosis of tumor cells and capable of discriminating between responsive and resistant tumor models.
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Anup Tank, Cameron Vergato, David J. Waxman, and Darren M. Roblyer "Optical scattering serves as a prognostic biomarker for immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model", Proc. SPIE PC11944, Multiscale Imaging and Spectroscopy III, PC1194407 (7 March 2022); https://doi.org/10.1117/12.2608388
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KEYWORDS
Scattering
Tumors
Breast cancer
Resistance
Tumor growth modeling
Cell death
In vivo imaging
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