Design and optimization of improved-resolution extended depth-of-field optical coherence tomography probes for imaging in swine esophagus

Chukwuemeka Okoro; Rachel Smith; Nitasha Bhat; Guillermo J. Tearney M.D.; Oscar Caravaca Mora

doi:10.1117/12.2609792

7 March 2022 Design and optimization of improved-resolution extended depth-of-field optical coherence tomography probes for imaging in swine esophagus

Chukwuemeka Okoro, Rachel Smith, Nitasha Bhat, Guillermo J. Tearney M.D., Oscar Caravaca Mora

Author Affiliations +

Proceedings Volume PC11951, Design and Quality for Biomedical Technologies XV; PC119510G (2022) https://doi.org/10.1117/12.2609792
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

High-resolution, extended depth-of-field (EDOF) optical coherence tomography (OCT) in tethered capsules can be achieved using a mirror-tunnel design, and then further modeled and optimized for enhanced performance. In this work, a model with initial dimensions yielded 13 µm full-width-at-half-maximum (FWHM) spot size over 1.5 mm DOF. An optimization algorithm produced a design that attained 8 µm FWHM over 1.5 mm DOF. The initial and optimized probes were fabricated, beam-profiled and integrated into capsules connected to a swept-source OCT system, for imaging swine esophagus in experiments. The resulting data comparison and analysis show the lateral resolution improvement achievable in optimized probes.

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Citation Download Citation

Chukwuemeka Okoro, Rachel Smith, Nitasha Bhat, Guillermo J. Tearney M.D., and Oscar Caravaca Mora "Design and optimization of improved-resolution extended depth-of-field optical coherence tomography probes for imaging in swine esophagus", Proc. SPIE PC11951, Design and Quality for Biomedical Technologies XV, PC119510G (7 March 2022); https://doi.org/10.1117/12.2609792

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