Dr. Nitasha G. M. Bhat Profile

Dr. Nitasha G. M. Bhat

Clinical Research Coordinator II at Massachusetts General Hospital

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Publications (9)

Proceedings Article | 19 March 2024 Presentation

OCT tethered capsule endomicroscopy targeted laser capture biopsy for detection of genetic biomarkers of esophageal cancer progression in Barrett’s esophagus patients

Fang Hou, Rachel Smith, Anita Chung, Tara Lignelli, Jansa Zachary, Nitasha G. Bhat, Catriona Grant, Matthew Stachler, Guillermo Tearney

Proceedings Volume PC12820, PC1282007 (2024) https://doi.org/10.1117/12.3008636

KEYWORDS: Biopsy, Esophagus, Cancer, Optical coherence tomography, Endomicroscopy, Target detection, Genetics, Cancer detection, Tissues, Endoscopy

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Proceedings Article | 7 March 2022 Presentation

Feasibility and safety of tethered capsule endomicroscopy in studying the natural history of Barrett’s esophagus: a multi-center study

Jing Dong, Catriona Grant, Barry Vuong, Norman Nishioka, Anna Huizi Gao, Matthew Beatty, Grace Baldwin, Aaron Bailargeon, Ara Bablouzian, Patricia Grahmann, Nitasha G. Bhat, Emily Ryan, Amilcar Barrios, Paola Leon Alarcon, Sarah Giddings, Tim Ford, Émilie Beaulieu-Ouellet, Seyed Hamid Hosseiny, Irene Lerman, Wolfgang Trasischker, Rohith Reddy, Kanwarpal Singh, Michalina Gora, Daryl Hyun, Lucille Quénéhervé, Michael Wallace, Wolfsen Herbert, Prateek Sharma, Kenneth Wang, Cadman Leggett, John Poneros, Julian Abrams, Charles Lightdale, Samantha Leeds, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume PC11937, PC119370N (2022) https://doi.org/10.1117/12.2610595

KEYWORDS: Esophagus, Optical coherence tomography, Endoscopy, Endomicroscopy, Safety, Tissues, Imaging systems, Biopsy, Diagnostics, Yield improvement

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Proceedings Article | 7 March 2022 Presentation

Design and optimization of improved-resolution extended depth-of-field optical coherence tomography probes for imaging in swine esophagus

Chukwuemeka Okoro, Rachel Smith, Nitasha Bhat, Guillermo Tearney, Oscar Caravaca Mora

Proceedings Volume PC11951, PC119510G (2022) https://doi.org/10.1117/12.2609792

KEYWORDS: Optical coherence tomography, Esophagus, Optical design, Waveguides, Wave propagation, Spatial frequencies, Performance modeling, Optimization (mathematics), Optical simulations, Near field

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Proceedings Article | 5 March 2021 Poster + Presentation

Screening for Barrett’s Esophagus in the primary care setting using tethered capsule endomicroscopy

Anita Chung, Anna Gao, Catriona Grant, Emily Ryan, Nitasha Bhat, Alfred Kyrollos Kelada, Amilcar Pojoy Barrios, Jing Dong, Aaron Baillargeon, Patricia Grahmann, Mikayla Tinus, Ara Bablouzian, Rachel Smith, Joshua Metlay, Leigh Simmons, Karen Blumenthal, Donna Krauth, Luis Henkel, Andrew Fauteux, Emily Brown, Katherine Wolcott, Guillermo Tearney

Proceedings Volume 11620, 116200H (2021) https://doi.org/10.1117/12.2577743

KEYWORDS: Optical coherence tomography, Esophagus, Endomicroscopy, Image segmentation, Microscopy

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Proceedings Article | 5 March 2021 Presentation

Non-invasive tethered capsule endomicroscopy imaging biomarkers for the diagnosis of the celiac disease from unsedated patients

Girish G. N., Paola A. Leon Alarcon, Amilcar Barrios, David O. Otuya, Jing Dong, Sarah Giddings, Nitasha Mudalaje, Catriona Grant, Joseph Gardecki, Norman Nishioka, Christopher Damman, Guillermo Tearney

Proceedings Volume 11620, 1162003 (2021) https://doi.org/10.1117/12.2584550

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Proceedings Article | 4 March 2019 Presentation

Minimally invasive trans-nasal biopsy of the small intestine (Conference Presentation)

David Otuya, Hamid Farrokhi, Jing Dong, Rachel Shore, Mason Schellenberg, Sarah Giddings, Nitasha Mudalaje, Catriona Grant, Aaron Baillargeon, Joseph Gardecki, Norman Nishioka, Christopher Damman, Guillermo Tearney

Proceedings Volume 10854, 108540M (2019) https://doi.org/10.1117/12.2510447

KEYWORDS: Biopsy, Intestine, Endoscopy, Optical coherence tomography, Metals, Absorption, Diagnostics, Gold, In vivo imaging, Tissues

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Proceedings Article | 4 March 2019 Presentation

Transnasal introduction catheter, a new platform for imaging and biopsying the gastrointestinal (GI) tract (Conference Presentation)

Hamid Farrokhi, Jing Dong, David Otuya, Yogesh Verma, Sarah Zemlok, Aditya Kumar, Rachel Shore, Sarah L. Giddings, Nitasha G. Bhat, Omair Shakil, Catriona Grant, Norman Nishioka, Mireille Rosenberg, Christopher Damman, Guillermo Tearney

Proceedings Volume 10854, 108540L (2019) https://doi.org/10.1117/12.2510381

KEYWORDS: Endoscopy, Biopsy, Optical coherence tomography, Stomach, Endomicroscopy, Tissues, Visualization, Francium, Real time imaging, Liquids

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Proceedings Article | 4 March 2019 Presentation

Duodenal imaging by tethered capsule OCT endomicroscopy in adolescents with environmental enteric dysfunction (Conference Presentation)

Jing Dong, Kamran Sadiq, Catriona Grant, Omair Shakil, David Otuya, Hamid Farrokhi, Anna Gao, Nitasha Bhat, Sarah Giddings, Kumail Ahmed, Seema Rani, Mireille Rosenberg, Alessio Fasano, Christopher Damman, Asad Ali, Guillermo Tearney

Proceedings Volume 10854, 1085408 (2019) https://doi.org/10.1117/12.2513965

KEYWORDS: Optical coherence tomography, Endomicroscopy, Intestine, Endoscopy, Inflammation, Biopsy, 3D image processing, Visualization, Control systems

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Environmental Enteric Dysfunction (EED) is a poorly understood condition of the small intestine that is prevalent in regions of the world with inadequate sanitation and hygiene. EED affects 25% of all children globally and causes over a million deaths each year. The condition is associated with increased intestinal permeability, bacterial translocation, inflammation and villous blunting. The loss of absorptive area and intestinal function leads to nutrient malabsorption, with long term outcomes characterized by stunted growth and neurocognitive development. Currently, the only way to directly evaluate the morphology of the intestine is endoscopy with mucosal biopsy. Yet because EED is endemic in low and middle-income countries, endoscopy is untenable for studying EED. As a result, the diagnosis of EED and the assessment of the efficacy of EED interventions is hampered by an inability to evaluate the intestinal mucosa. Our lab has previously developed a technology termed tethered capsule OCT endomicroscopy (TCE). The method involves swallowing an optomechanically-engineered pill that generates 3D images of the GI tract as it traverses the lumen of the organ via peristalsis, assisted by gravity. In order to study the potential of using TCE to investigate EED, we initiated and conducted a TCE study in adolescents at Aga Khan Medical Center in Pakistan. To make swallowing easier, the tethered capsule’s size was reduced from 11x25 mm to 8x22 mm. Villous morphologic visualization was enhanced by building a notch (x mm deep, y mm wide) in the capsule’s imaging window. To date, 26 Pakistani subjects with ages ranging from 14 to 18 y/o (16.4 +/- 1.0) have been enrolled and imaged. A total of 19 subjects were able to swallow the capsule. Of those, 9 successfully passed through the pylorus, allowing successful microscopic imaging of the entire duodenum. There were no adverse events in any of the cases. Maximum villous height and width were measured from 3 randomly chosen, representative frames from each Pakistan subject as well as a matching number from US controls. Preliminary results, comparing Pakistani vs US villous morphology, indicated that subjects from Pakistan have shorter (628.6 +/- 22.0 um and 492.3 +/- 13.2 um, respectively, p< 0.0001) and wider duodenal villi (244.9 +/- 8.8 um and 293.4 +/- 13.2 um, respectively, p< 0.0001). These findings suggest that OCT TCE of the duodenum may be a useful tool for evaluating villous morphology in EED.

Proceedings Article | 14 March 2018 Presentation

Trans-nasal OCT imaging of the small intestine (Conference Presentation)

David Otuya, Yogesh Verma, Jing Dong, Hamid Farrokhi, Sarah Giddings, Nitasha G. Bhat, Omair Shakil, Catriona Grant, Guillermo Tearney

Proceedings Volume 10470, 104700Z (2018) https://doi.org/10.1117/12.2290732

KEYWORDS: Optical coherence tomography, Intestine, Coherence imaging, Francium, Imaging devices

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