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2 March 2022 Laser speckle rheological microscopy of the breast carcinoma microenvironment
Zeinab Hajjarian Kashany, Elena F. Brachtel, Diane M. Tshikudi, Seemantini K. Nadkarni
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Proceedings Volume PC11962, Optical Elastography and Tissue Biomechanics VIV; PC1196208 (2022) https://doi.org/10.1117/12.2610690
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Altered tissue stiffness has raised as both the cause and the consequence of breast tumorigenesis. Imaging the heterogeneous mechanical properties of tissue microenvironment provides crucial insights into micro-mechanical drivers of carcinogenesis. Here, we introduce laser Speckle rHEologicAl micRoscopy (SHEAR), which enables mapping the frequency-dependent shear viscoelastic modulus, G*(x,y,ω), with a spatial resolution of < 50 mm, over multiple cm2, in solid tumors within minutes. SHEAR mapping in a cohort of excised breast specimens demonstrates that |G*(x,y)| closely agrees with tumor histopathology, its gradient, |∇|G*(x,y,ω)||, is increased at the tumor invasive front, and both metrics are associated with tumor prognosis.
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Zeinab Hajjarian Kashany, Elena F. Brachtel, Diane M. Tshikudi, and Seemantini K. Nadkarni "Laser speckle rheological microscopy of the breast carcinoma microenvironment", Proc. SPIE PC11962, Optical Elastography and Tissue Biomechanics VIV, PC1196208 (2 March 2022); https://doi.org/10.1117/12.2610690
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KEYWORDS
Tumors
Breast
Microscopy
Speckle
Elastography
In vitro testing
Lymphatic system
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