Reliable and easy-to-use SERS spectroscopy platform based on a tapered opto-fluidic photonic crystal fiber

Amine Benazza; Flavien Beffara; Jean-Louis Auguste; Dinish U.S.; Malini Olivo; Georges J. Humbert

doi:10.1117/12.2651644

6 March 2023 Reliable and easy-to-use SERS spectroscopy platform based on a tapered opto-fluidic photonic crystal fiber

Amine Benazza, Flavien Beffara, Jean-Louis Auguste, Dinish U.S., Malini Olivo, Georges J. Humbert

Proceedings Volume PC12372, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXIII; PC1237203 (2023) https://doi.org/10.1117/12.2651644
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Surface enhanced Raman scattering (SERS) is a powerful biosensing technique allowing direct detection of target molecules thanks to their vibrational fingerprint Raman spectra. SERS is usually performed on nano roughened plamonic planar substrates/colloidal nanoparticles. However, the irregularities of plasmonic nanostructures lead to measurement reliability limitations. We have recently demonstrated that SERS-probes based on opto-fluidic photonic crystal fiber (PCF) composed of a silica-core surrounded by large air channels are remarkable sensing platforms leading to tremendous SERS sensitivity and excellent measurement reliability (98% in reproducibility and 95% in repeatability). However, a major limitation occurs when looking for highly reliable and easy-to-use biosensing platform. Actual SERS biosensors (planar substrate or fiber probe) require their alignment under a microscope, which could restrict on-field practical use. Here, we address this issue by developing a tapered opto-fluidic PCF allowing excellent reliability, efficient and easy coupling through a Plug-&-Play type modality. This novel type of SERS probe realized by reducing the fiber diameter, which increases the SERS sensitivity while enabling efficient light coupling to the Raman spectrometer with a relative standard deviation (RSD) of only 3.5% in reproducibility and 3.84% in repeatability. We demonstrate this easy Plug-&-Play type coupling based on a simple bare fiber connector, with a RSD of 4.5% in reproducibility measurements (i.e. removing and reconnecting the fiber SERS-probe to the Raman spectrometer without any additional alignment). We envision that this easy-to-use platform can be translated to - clinically viable SERS probes for liquid biopsy.

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Amine Benazza, Flavien Beffara, Jean-Louis Auguste, Dinish U.S., Malini Olivo, and Georges J. Humbert "Reliable and easy-to-use SERS spectroscopy platform based on a tapered opto-fluidic photonic crystal fiber", Proc. SPIE PC12372, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXIII, PC1237203 (6 March 2023); https://doi.org/10.1117/12.2651644

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KEYWORDS

Surface enhanced Raman spectroscopy

Optofluidics

Photonic crystal fibers

Raman spectroscopy

Reliability

Biosensing

Spectroscopy

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