Laser-assisted fabrication of 3D engineered cell microenvironments: the new era of mechanobiology

Angelo Accardo

doi:10.1117/12.3008978

17 October 2023 Laser-assisted fabrication of 3D engineered cell microenvironments: the new era of mechanobiology

Angelo Accardo

Proceedings Volume PC12741, Advanced Materials, Biomaterials, and Manufacturing Technologies for Security and Defence; PC127410B (2023) https://doi.org/10.1117/12.3008978
Event: SPIE Security + Defence, 2023, Amsterdam, Netherlands

Abstract

Our body is composed by unit blocks: organs, tissues and, ultimately, cells. Understanding the functioning of cells in health and disease, plays a fundamental role for future tissue engineering and drug-discovery applications. However, current cell biology protocols are limited to 2D cultures, which, although inexpensive and easy to handle, do not reproduce the complexity of real tissues. In this talk, I show how to surpass these conventional approaches by realizing biomimetic 3D microstructures for both fundamental cell mechanobiology and in-vitro disease/treatment modeling. The focus will be on the most recent results of our research activity, which exploits laser-assisted 3D printing for the creation of biomimetic microenvironments dedicated to three types of tissue: brain, brain cancer and bone.

Conference Presentation

Citation Download Citation

Angelo Accardo "Laser-assisted fabrication of 3D engineered cell microenvironments: the new era of mechanobiology", Proc. SPIE PC12741, Advanced Materials, Biomaterials, and Manufacturing Technologies for Security and Defence, PC127410B (17 October 2023); https://doi.org/10.1117/12.3008978

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