Dr. Angelo Accardo Profile

Dr. Angelo Accardo

at Delft University of Technology

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Proceedings Article | 17 October 2023 Presentation

Laser-assisted fabrication of 3D engineered cell microenvironments: the new era of mechanobiology

Angelo Accardo

Proceedings Volume PC12741, PC127410B (2023) https://doi.org/10.1117/12.3008978

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Our body is composed by unit blocks: organs, tissues and, ultimately, cells. Understanding the functioning of cells in health and disease, plays a fundamental role for future tissue engineering and drug-discovery applications. However, current cell biology protocols are limited to 2D cultures, which, although inexpensive and easy to handle, do not reproduce the complexity of real tissues. In this talk, I show how to surpass these conventional approaches by realizing biomimetic 3D microstructures for both fundamental cell mechanobiology and in-vitro disease/treatment modeling. The focus will be on the most recent results of our research activity, which exploits laser-assisted 3D printing for the creation of biomimetic microenvironments dedicated to three types of tissue: brain, brain cancer and bone.

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