OCT tethered capsule endomicroscopy targeted laser capture biopsy for detection of genetic biomarkers of esophageal cancer progression in Barrett’s esophagus patients

Fang Hou; Rachel Smith; Anita S. Chung; Tara C. Lignelli; Jansa D. Zachary; Nitasha G. M. Bhat; Catriona N. Grant; Matthew D. Stachler; Guillermo J. Tearney

doi:10.1117/12.3008636

19 March 2024 OCT tethered capsule endomicroscopy targeted laser capture biopsy for detection of genetic biomarkers of esophageal cancer progression in Barrett’s esophagus patients

Fang Hou, Rachel Smith, Anita S. Chung, Tara C. Lignelli, Jansa D. Zachary, Nitasha G. M. Bhat, Catriona N. Grant, Matthew D. Stachler, Guillermo J. Tearney

Author Affiliations +

Proceedings Volume PC12820, Endoscopic Microscopy XIX; PC1282007 (2024) https://doi.org/10.1117/12.3008636
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Screening of Barrett’s Esophagus (BE) for progression to esophageal adenocarcinoma with standard endoscopic biopsy is expensive, invasive, and imprecise due to sampling error and the limited value of histomorphology for predicting cancer risk. We have developed a technology called in vivo laser capture microdissection (IVLCM) that overcomes these issues by using OCT tethered capsule endomicroscopy (OCT-TCE) to image the entire esophagus at the microscopic level. Pilot clinical study results show that IVLCM samples provide sufficient DNA material for genetic sequencing. The comparison of sequencing quality and gene mapping of IVLCM samples and conventional FFPE biopsy samples will be analyzed in the ongoing clinical study.

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Fang Hou, Rachel Smith, Anita S. Chung, Tara C. Lignelli, Jansa D. Zachary, Nitasha G. M. Bhat, Catriona N. Grant, Matthew D. Stachler, and Guillermo J. Tearney "OCT tethered capsule endomicroscopy targeted laser capture biopsy for detection of genetic biomarkers of esophageal cancer progression in Barrett’s esophagus patients", Proc. SPIE PC12820, Endoscopic Microscopy XIX, PC1282007 (19 March 2024); https://doi.org/10.1117/12.3008636

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