Catheter-based diffuse reflectance spectroscopy for cardiac substrate mapping

Jonah A. Majumder; Haiqiu Yang; Ziyi Huang; Aidan Therien; Kenneth Laurita; Andrew Rollins; Deepak Saluja; Christine P. Hendon

doi:10.1117/12.3001935

13 March 2024 Catheter-based diffuse reflectance spectroscopy for cardiac substrate mapping

Jonah A. Majumder, Haiqiu Yang, Ziyi Huang, Aidan Therien, Kenneth Laurita, Andrew Rollins, Deepak Saluja, Christine P. Hendon

Author Affiliations +

Proceedings Volume PC12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC128360B (2024) https://doi.org/10.1117/12.3001935
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Atrial fibrillation is a common and potentially lethal arrhythmia, yet catheter radiofrequency ablation (RFA), a mainstay of treatment, frequently fails to provide long-term remission. We present a catheter capable of near-infrared diffuse reflectance spectroscopy, with a source fiber delivering broadband light and a detection fiber whose light is sent to a spectrometer. Separate catheters have been fabricated with different source-detection separations, yielding spectra sensitive to different optical properties of the underlying tissue. Optical indices have been developed from benchtop measurements to distinguish the spectral signatures of different cardiac substrates. These measurements will equip clinicians with intraprocedural feedback to improve RFA effectiveness.

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Citation Download Citation

Jonah A. Majumder, Haiqiu Yang, Ziyi Huang, Aidan Therien, Kenneth Laurita, Andrew Rollins, Deepak Saluja, and Christine P. Hendon "Catheter-based diffuse reflectance spectroscopy for cardiac substrate mapping", Proc. SPIE PC12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC128360B (13 March 2024); https://doi.org/10.1117/12.3001935

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KEYWORDS

Diffuse reflectance spectroscopy

Ablation

Atrial fibrillation

Radiofrequency ablation

Tissues

Biological samples

Photons

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