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13 March 2024 Low-cost end-user photo-thermal device for sensitive detection and quantification of analytes in fluidic samples
Derek Hayden, Baseer Yousufzai, Raha Golsorkhi, Nakisa Samadi, Nima Tabatabaei
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Proceedings Volume PC12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics; PC1285004 (2024) https://doi.org/10.1117/12.3001793
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Performance of paper-based rapid tests is limited by their poor limit of detection and binary response. We have developed a low-cost end-user device that overcomes the classic limitations of rapid tests. The Arduino-based hand-held device excites rapid test gold nanoparticles with modulated 532nm LED while recording their thermal wave response with low-cost thermometer ICs. Validation studies on COVID-19 antibodies and THC (psychoactive constituent of cannabis) in saliva demonstrates ability of the innovation in quantifying analyte concentrations and enhancing the limit of detection by over an order of magnitude.
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Derek Hayden, Baseer Yousufzai, Raha Golsorkhi, Nakisa Samadi, and Nima Tabatabaei "Low-cost end-user photo-thermal device for sensitive detection and quantification of analytes in fluidic samples", Proc. SPIE PC12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics, PC1285004 (13 March 2024); https://doi.org/10.1117/12.3001793
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KEYWORDS
Statistical analysis
Gold nanoparticles
COVID 19
Data modeling
Modeling
Control systems
Demodulation
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