Infrared spectroscopic imaging of renal tumor tissue

Valdas Sablinskas; Vidita Urboniene; Justinas Ceponkus; Arvydas Laurinavicius; Darius Dasevicius; Feliksas Jankevicius; Vaiva Hendrixson; Edmund Koch; Gerald Steiner

doi:10.1117/1.3622292

1 September 2011 Infrared spectroscopic imaging of renal tumor tissue

Valdas Sablinskas, Vidita Urboniene, Justinas Ceponkus, Arvydas Laurinavicius, Darius Dasevicius, Feliksas Jankevicius, Vaiva Hendrixson, Edmund Koch, Gerald Steiner

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Journal of Biomedical Optics, Vol. 16, Issue 9, 096006 (September 2011). https://doi.org/10.1117/1.3622292

Abstract

Fourier transform infrared (FTIR) spectroscopic imaging has been used to probe the biochemical composition of human renal tumor tissue and adjacent normal tissue. Freshly resected renal tumor tissue from surgery was prepared as a thin cryosection and examined by FTIR spectroscopic imaging. Tissue types could be discriminated by utilizing a combination of fuzzy k-means cluster analysis and a supervised classification algorithm based on a linear discriminant analysis. The spectral classification is compared and contrasted with the histological stained image. It is further shown that renal tumor cells have spread in adjacent normal tissue. This study demonstrates that FTIR spectroscopic imaging can potentially serve as a fast and objective approach for discrimination of renal tumor tissue from normal tissue and even in the detection of tumor infiltration in adjacent tissue.

©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Valdas Sablinskas, Vidita Urboniene, Justinas Ceponkus, Arvydas Laurinavicius, Darius Dasevicius, Feliksas Jankevicius, Vaiva Hendrixson, Edmund Koch, and Gerald Steiner "Infrared spectroscopic imaging of renal tumor tissue," Journal of Biomedical Optics 16(9), 096006 (1 September 2011). https://doi.org/10.1117/1.3622292

Published: 1 September 2011

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