Phase-resolved acoustic radiation force optical coherence elastography

Wenjuan Qi; Ruimin Chen; Lidek Chou; Gangjun Liu; Jun Zhang; Qifa Zhou; Zhongping Chen

doi:10.1117/1.JBO.17.11.110505

2 November 2012 Phase-resolved acoustic radiation force optical coherence elastography

Wenjuan Qi, Ruimin Chen, Lidek Chou, Gangjun Liu, Jun Zhang, Qifa Zhou, Zhongping Chen

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Journal of Biomedical Optics, Vol. 17, Issue 11, 110505 (November 2012). https://doi.org/10.1117/1.JBO.17.11.110505

Abstract

Many diseases involve changes in the biomechanical properties of tissue, and there is a close correlation between tissue elasticity and pathology. We report on the development of a phase-resolved acoustic radiation force optical coherence elastography method (ARF-OCE) to evaluate the elastic properties of tissue. This method utilizes chirped acoustic radiation force to produce excitation along the sample's axial direction, and it uses phase-resolved optical coherence tomography (OCT) to measure the vibration of the sample. Under 500-Hz square wave modulated ARF signal excitation, phase change maps of tissue mimicking phantoms are generated by the ARF-OCE method, and the resulting Young's modulus ratio is correlated with a standard compression test. The results verify that this technique could efficiently measure sample elastic properties accurately and quantitatively. Furthermore, a three-dimensional ARF-OCE image of the human atherosclerotic coronary artery is obtained. The result indicates that our dynamic phase-resolved ARF-OCE method can delineate tissues with different mechanical properties.

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Wenjuan Qi, Ruimin Chen, Lidek Chou, Gangjun Liu, Jun Zhang, Qifa Zhou, and Zhongping Chen "Phase-resolved acoustic radiation force optical coherence elastography," Journal of Biomedical Optics 17(11), 110505 (2 November 2012). https://doi.org/10.1117/1.JBO.17.11.110505

Published: 2 November 2012

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KEYWORDS

Tissues

Optical coherence tomography

Acoustics

Elastography

Coherence (optics)

Arteries

Modulation

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