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14 June 2012 Evaluation of human sclera after femtosecond laser ablation using two photon and confocal microscopy
Hui Sun, Ronald M. Kurtz M.D., Tibor Juhasz
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Journal of Biomedical Optics, Vol. 17, Issue 8, 081411 (June 2012). https://doi.org/10.1117/1.JBO.17.8.081411
Abstract
Glaucoma is the second-leading cause of blindness worldwide and is often associated with elevated intraocular pressure (IOP). Partial thickness intrascleral channels can be created with a femtosecond laser operating at a wavelength of 1700 nm. Such channels have the potential to increase outflow facility and reduce elevated IOP. Analysis of the dimensions and location of these channels is important in understanding their effects. We describe the application of two-photon microscopy and confocal microscopy for noninvasive imaging of the femtosecond laser created partial-thickness scleral channels in human cadaver eyes. High-resolution images, hundreds of microns deep in the sclera, were obtained to allow determination of the shape and dimension of such channels. This demonstrates that concept of integrating femtosecond laser surgery, and two-photon and confocal imaging has the future potential for image-guided high-precision surgery in transparent and translucent tissue.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Hui Sun, Ronald M. Kurtz M.D., and Tibor Juhasz "Evaluation of human sclera after femtosecond laser ablation using two photon and confocal microscopy," Journal of Biomedical Optics 17(8), 081411 (14 June 2012). https://doi.org/10.1117/1.JBO.17.8.081411
Published: 14 June 2012
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KEYWORDS
Femtosecond phenomena
Sclera
Confocal microscopy
Laser ablation
Second-harmonic generation
Two photon confocal microscopy
Microscopes
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