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2 January 2015 Shear wave elastography using amplitude-modulated acoustic radiation force and phase-sensitive optical coherence tomography
Thu-Mai Nguyen, Bastien Arnal, Shaozhen Song, Zhihong Huang, Ruikang K. Wang, Matthew O’Donnell
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Journal of Biomedical Optics, Vol. 20, Issue 1, 016001 (January 2015). https://doi.org/10.1117/1.JBO.20.1.016001
Abstract
Investigating the elasticity of ocular tissue (cornea and intraocular lens) could help the understanding and management of pathologies related to biomechanical deficiency. In previous studies, we introduced a setup based on optical coherence tomography for shear wave elastography (SWE) with high resolution and high sensitivity. SWE determines tissue stiffness from the propagation speed of shear waves launched within tissue. We proposed acoustic radiation force to remotely induce shear waves by focusing an ultrasound (US) beam in tissue, similar to several elastography techniques. Minimizing the maximum US pressure is essential in ophthalmology for safety reasons. For this purpose, we propose a pulse compression approach. It utilizes coded US emissions to generate shear waves where the energy is spread over a long emission, and then numerically compressed into a short, localized, and high-energy pulse. We used a 7.5-MHz single-element focused transducer driven by coded excitations where the amplitude is modulated by a linear frequency-swept square wave (1 to 7 kHz). An inverse filter approach was used for compression. We demonstrate the feasibility of performing shear wave elastography measurements in tissue-mimicking phantoms at low US pressures (mechanical index <0.6).
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Thu-Mai Nguyen, Bastien Arnal, Shaozhen Song, Zhihong Huang, Ruikang K. Wang, and Matthew O’Donnell "Shear wave elastography using amplitude-modulated acoustic radiation force and phase-sensitive optical coherence tomography," Journal of Biomedical Optics 20(1), 016001 (2 January 2015). https://doi.org/10.1117/1.JBO.20.1.016001
Published: 2 January 2015
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Cited by 51 scholarly publications and 2 patents.
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KEYWORDS
Elastography
Tissues
Optical coherence tomography
Signal to noise ratio
Acoustics
Wave propagation
Transducers
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