Integration of a Raman spectroscopy system to a robotic-assisted surgical system for real-time tissue characterization during radical prostatectomy procedures

Michael Pinto; Kevin C. Zorn; Jean-Philippe Tremblay; Joannie Desroches; Frédérick Dallaire; Kelly Aubertin; Eric T. Marple; Chris Kent; Frederic Leblond; Dominique Trudel; Frederic Lesage

doi:10.1117/1.JBO.24.2.025001

14 February 2019 Integration of a Raman spectroscopy system to a robotic-assisted surgical system for real-time tissue characterization during radical prostatectomy procedures

Michael Pinto, Kevin C. Zorn, Jean-Philippe Tremblay, Joannie Desroches, Frédérick Dallaire, Kelly Aubertin, Eric T. Marple, Chris Kent, Frederic Leblond, Dominique Trudel, Frederic Lesage

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Journal of Biomedical Optics, Vol. 24, Issue 2, 025001 (February 2019). https://doi.org/10.1117/1.JBO.24.2.025001

Abstract

Surgical excision of the whole prostate through a radical prostatectomy procedure is part of the standard of care for prostate cancer. Positive surgical margins (cancer cells having spread into surrounding nonresected tissue) occur in as many as 1 in 5 cases and strongly correlate with disease recurrence and the requirement of adjuvant treatment. Margin assessment is currently only performed by pathologists hours to days following surgery and the integration of a real-time surgical readout would benefit current prostatectomy procedures. Raman spectroscopy is a promising technology to assess surgical margins: its in vivo use during radical prostatectomy could help insure the extent of resected prostate and cancerous tissue is maximized. We thus present the design and development of a dual excitation Raman spectroscopy system (680- and 785-nm excitations) integrated to the robotic da Vinci surgical platform for in vivo use. Following validation in phantoms, spectroscopic data from 20 whole human prostates immediately following radical prostatectomy are obtained using the system. With this dataset, we are able to distinguish prostate from extra prostatic tissue with an accuracy, sensitivity, and specificity of 91%, 90.5%, and 96%, respectively. Finally, the integrated Raman spectroscopy system is used to collect preliminary spectroscopic data at the surgical margin in vivo in four patients.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Michael Pinto, Kevin C. Zorn, Jean-Philippe Tremblay, Joannie Desroches, Frédérick Dallaire, Kelly Aubertin, Eric T. Marple, Chris Kent, Frederic Leblond, Dominique Trudel, and Frederic Lesage "Integration of a Raman spectroscopy system to a robotic-assisted surgical system for real-time tissue characterization during radical prostatectomy procedures," Journal of Biomedical Optics 24(2), 025001 (14 February 2019). https://doi.org/10.1117/1.JBO.24.2.025001

Received: 2 August 2018; Accepted: 21 November 2018; Published: 14 February 2019

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