CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 29 > Issue S1 > Article
Open Access
13 January 2024 Acoustic resolution photoacoustic Doppler flowmetry for assessment of patient rectal cancer blood perfusion
Sitai Kou, Xiandong Leng, Hongbo Luo, Haolin Nie, Quing Zhu
Author Affiliations +
Journal of Biomedical Optics, Vol. 29, Issue S1, S11517 (January 2024). https://doi.org/10.1117/1.JBO.29.S1.S11517
Abstract

Significance

Photoacoustic Doppler flowmetry offers quantitative blood perfusion information in addition to photoacoustic vascular contrast for rectal cancer assessment.

Aim

We aim to develop and validate a correlational Doppler flowmetry utilizing an acoustic resolution photoacoustic microscopy (AR-PAM) system for blood perfusion analysis.

Approach

To extract blood perfusion information, we implemented AR-PAM Doppler flowmetry consisting of signal filtering and conditioning, A-line correlation, and angle compensation. We developed flow phantoms and contrast agent to systemically investigate the flowmetry’s efficacy in a series of phantom studies. The developed correlational Doppler flowmetry was applied to images collected during in vivo AR-PAM for post-treatment rectal cancer evaluation.

Results

The linearity and accuracy of the Doppler flow measurement system were validated in phantom studies. Imaging rectal cancer patients treated with chemoradiation demonstrated the feasibility of using correlational Doppler flowmetry to assess treatment response and distinguish residual cancer from cancer-free tumor bed tissue and normal rectal tissue.

Conclusions

A new correlational Doppler flowmetry was developed and validated through systematic phantom evaluations. The results of its application to in vivo patients suggest it could be a useful addition to photoacoustic endoscopy for post-treatment rectal cancer assessment.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Citation Download Citation
Sitai Kou, Xiandong Leng, Hongbo Luo, Haolin Nie, and Quing Zhu "Acoustic resolution photoacoustic Doppler flowmetry for assessment of patient rectal cancer blood perfusion," Journal of Biomedical Optics 29(S1), S11517 (13 January 2024). https://doi.org/10.1117/1.JBO.29.S1.S11517
Received: 18 September 2023; Accepted: 21 December 2023; Published: 13 January 2024
JOURNAL ARTICLE
 11 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Doppler effect
Tissues
Cancer
Photoacoustic spectroscopy
Tumors
Acoustics
In vivo imaging
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top