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3 July 2019 Handheld spectrally encoded coherence tomography and reflectometry for motion-corrected ophthalmic optical coherence tomography and optical coherence tomography angiography
Joseph D. Malone, Mohamed T. El-Haddad, Suhaas S. Yerramreddy, Ipek Oguz, Yuankai K. K. Tao
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Neurophotonics, Vol. 6, Issue 4, 041102 (July 2019). https://doi.org/10.1117/1.NPh.6.4.041102
Abstract
Optical coherence tomography (OCT) is the gold standard for quantitative ophthalmic imaging. The majority of commercial and research systems require patients to fixate and be imaged in a seated upright position, which limits the ability to perform ophthalmic imaging in bedridden or pediatric patients. Handheld OCT devices overcome this limitation, but image quality often suffers due to a lack of real-time aiming and patient eye and photographer motion. We describe a handheld spectrally encoded coherence tomography and reflectometry (SECTR) system that enables simultaneous en face reflectance and cross-sectional OCT imaging. The handheld probe utilizes a custom double-pass scan lens for fully telecentric OCT scanning with a compact optomechanical design and a rapid-prototyped enclosure to reduce the overall system size and weight. We also introduce a variable velocity scan waveform that allows for simultaneous acquisition of densely sampled OCT angiography (OCTA) volumes and widefield reflectance images, which enables high-resolution vascular imaging with precision motion-tracking for volumetric motion correction and multivolumetric mosaicking. Finally, we demonstrate in vivo human retinal OCT and OCT angiography (OCTA) imaging using handheld SECTR on a healthy volunteer. Clinical translation of handheld SECTR will allow for high-speed, motion-corrected widefield OCT and OCTA imaging in bedridden and pediatric patients who may benefit ophthalmic disease diagnosis and monitoring.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Joseph D. Malone, Mohamed T. El-Haddad, Suhaas S. Yerramreddy, Ipek Oguz, and Yuankai K. K. Tao "Handheld spectrally encoded coherence tomography and reflectometry for motion-corrected ophthalmic optical coherence tomography and optical coherence tomography angiography," Neurophotonics 6(4), 041102 (3 July 2019). https://doi.org/10.1117/1.NPh.6.4.041102
Received: 8 April 2019; Accepted: 12 June 2019; Published: 3 July 2019
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Cited by 22 scholarly publications.
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KEYWORDS
Optical coherence tomography
Coherence (optics)
Imaging systems
Reflectometry
Tomography
Angiography
Optical fibers
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