Dr. Chen Xu Profile

Dr. Chen Xu

Assistant Professor at New York City College of Technology

SPIE Involvement:

Author

Publications (21)

SPIE Journal Paper | 22 October 2018 Open Access

Compact ultrasound-guided diffuse optical tomography system for breast cancer imaging

Hamed Vavadi, Atahar Mostafa, Feifei Zhou, K. M. Shihab Uddin, Murad Althobaiti, Chen Xu, Rajeev Bansal, Foluso Ademuyiwa, Steven Poplack, Quing Zhu

JBO, Vol. 24, Issue 02, 021203, (October 2018) https://doi.org/10.1117/12.10.1117/1.JBO.24.2.021203

KEYWORDS: Imaging systems, Breast cancer, Diffuse optical tomography, Absorption, Tumors, Diffuse optical imaging, Mammography, Semiconductor lasers, Calibration, Sensors

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 17 February 2017 Paper

Preliminary results of miniaturized and robust ultrasound guided diffuse optical tomography system for breast cancer detection

Hamed Vavadi, Atahar Mostafa, Jinglong Li, Feifei Zhou, Shihab Uddin, Chen Xu, Quing Zhu

Proceedings Volume 10059, 100590F (2017) https://doi.org/10.1117/12.2250034

KEYWORDS: Breast imaging, Diffuse optical imaging, Breast cancer, Diffuse optical tomography, Ultrasonography, Cancer, Near infrared, Breast, Prototyping, Optical tomography, Absorption, Magnetic resonance imaging, Signal detection, Mammography, Tumors

Read Abstract +

Proceedings Article | 12 March 2015 Paper

Development of a robust and fast calibration procedure for diffuse optical tomography

Chen Xu, Hai Li, Guangqian Yuan, Hamed Vavadi, Quing Zhu

Proceedings Volume 9319, 93192E (2015) https://doi.org/10.1117/12.2084980

KEYWORDS: Calibration, Diffuse optical tomography, Data processing, Ultrasonography, Sensors, Near infrared, Breast, Data acquisition, Tumors, Optical properties

Read Abstract +

Proceedings Article | 12 March 2015 Paper

The effect and correction of reference heterogeneity in diffuse optical tomography

Hamed Vavadi, Chen Xu, Quing Zhu

Proceedings Volume 9319, 93192D (2015) https://doi.org/10.1117/12.2084936

KEYWORDS: Breast, Absorption, Diffuse optical tomography, Tumors, Near infrared, Optical properties, Sensors, Tissues, Breast cancer, Absorption filters

Read Abstract +

SPIE Journal Paper | 16 December 2013 Open Access

Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography

Chen Xu, Patrick Kumavor, Umar Alqasemi, Hai Li, Yan Xu, Saeid Zanganeh, Quing Zhu

JBO, Vol. 18, Issue 12, 126006, (December 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.12.126006

KEYWORDS: Acquisition tracking and pointing, Tumors, Ultrasonography, Absorption, Diffuse optical tomography, Indocyanine green, Tissue optics, Photoacoustic spectroscopy, Optical fibers, Bladder

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 25 March 2013 Paper

ICG enhanced co-registered diffuse optical tomography and photoacoustic tomography

Chen Xu, Patrick Kumavor, Yan Xu, Quing Zhu

Proceedings Volume 8578, 85780Y (2013) https://doi.org/10.1117/12.2005967

KEYWORDS: Acquisition tracking and pointing, Tumors, Diffuse optical tomography, Tissue optics, Photoacoustic tomography, Breast, Absorption, Ultrasonography, Optical fibers, Near infrared

Read Abstract +

SPIE Journal Paper | 7 May 2012 Open Access

Investigation of a diffuse optical measurements-assisted quantitative photoacoustic tomographic method in reflection geometry

Chen Xu, Patrick Kumavor, Andres Aguirre, Quing Zhu

JBO, Vol. 17, Issue 6, 061213, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.6.061213

KEYWORDS: Optical properties, Absorption, Acquisition tracking and pointing, Optical testing, Photoacoustic spectroscopy, Transducers, Ultrasonography, Optical fibers, Biomedical optics, Calibration

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 23 February 2012 Paper

Investigation of a quantitative photoacoustic tomography fitting procedure on multiple targets in reflection geometry with diffuse optical measurement assistance

Chen Xu, Patrick Kumavor, Quing Zhu

Proceedings Volume 8223, 822349 (2012) https://doi.org/10.1117/12.914364

KEYWORDS: Absorption, Acquisition tracking and pointing, Photoacoustic spectroscopy, Optical properties, Photoacoustic tomography, Breast, Tissue optics, Optical testing, Ultrasonography, Imaging systems

Read Abstract +

Traditional Photoacoustic tomography provides the distribution of absorbed optical energy densities which are the products of the optical absorption coefficients and fluences. However, the absorption coefficient is the only functional parameter that is related to disease diagnosis, such as cancer. In this paper, we report the experimental investigation of an improved fitting procedure which can quantitatively characterize optical absorption coefficients of multiple targets. The original fitting procedure was proposed by us and used for a single target. The fitting procedure included a complete photoacoustic forward model, which incorporated an analytical model of light transport and a model of acoustic propagation. Using the target information from the PAT images and the background information from diffuse optical measurements (DOM), the fitting method minimizes the photoacoustic measurements and forward model data and recovers the target absorption coefficient quantitatively. The fitting errors in the absorption coefficients can reach 20% to 100% if the original fitting procedure is directly used on multiple targets. In our improved fitting method, the ratio between the photoacoustic intensities is introduced and served as extra input to the fitting procedure. As a result, the total number of unknown parameters is reduced and fitting accuracy is improved. The hybrid system used in the experiment combines a 64-channel photoacoustic system with a frequency-domain diffused optical system. The experiment was performed in the reflection geometry suitable for breast imaging. Phantom experiments include the combination of high contrast and low contrast targets with absorption coefficients ranging from 0.07 to 0.28 cm^-1 and with different spatial separations. The phantoms were inserted into a chicken breast tissue. The fitting errors of multiple targets were reduced to less than 20% for both high and low contrast targets. These results illustrate the potential application of this quantitative DOM-assisted photoacoustic fitting procedure to image and diagnose breast cancer having multiple and complex tumor distribution.

SPIE Journal Paper | 1 July 2011 Open Access

Clustered targets imaged by optical tomography guided by ultrasound

Yan Xu, Chen Xu, Quing Zhu

JBO, Vol. 16, Issue 07, 076018, (July 2011) https://doi.org/10.1117/12.10.1117/1.3600773

KEYWORDS: Absorption, Target designation, Ultrasonography, Optical tomography, Reconstruction algorithms, Satellites, Sensors, Breast, Computer simulations, Optical properties

Read Abstract +

DOWNLOAD PAPER

SPIE Journal Paper | 1 April 2011 Open Access

Errata: Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system

Patrick Kumavor, Chen Xu, Andres Aguirre, John Gamelin, Yasaman Ardeshirpour, Behnoosh Tavakoli, Saeid Zanganeh, Umar Alqasemi, Yi Yang, Quing Zhu

JBO, Vol. 16, Issue 04, 049802, (April 2011) https://doi.org/10.1117/12.10.1117/1.3587643

KEYWORDS: Target detection, Diffuse optical tomography, Photoacoustic tomography, Computing systems, Computer engineering, Photoacoustic spectroscopy, Optical spheres

DOWNLOAD PAPER

SPIE Journal Paper | 1 April 2011 Open Access

Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system

Patrick Kumavor, Chen Xu, Andres Aguirre, John Gamelin, Yasaman Ardeshirpour, Behnoosh Tavakoli, Saeid Zanganeh, Umar Alqasemi, Yi Yang, Quing Zhu

JBO, Vol. 16, Issue 04, 046010, (April 2011) https://doi.org/10.1117/12.10.1117/1.3563534

KEYWORDS: Absorption, Acquisition tracking and pointing, Target detection, Diffuse optical tomography, Transducers, Ultrasonography, Photoacoustic spectroscopy, Optical properties, Imaging systems, Photoacoustic tomography

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 1 March 2011 Paper

Target detection and characterization using a hybrid handheld diffuse optical tomography and photoacoustic tomography system

Patrick Kumavor, Andres Aguirre, Chen Xu, John Gamelin, Yasaman Ardeshirpour, Behnoosh Tavakoli, Saeid Zanganeh, Umar Alqasemi, Quing Zhu

Proceedings Volume 7896, 789614 (2011) https://doi.org/10.1117/12.878913

KEYWORDS: Acquisition tracking and pointing, Absorption, Optical fibers, Target detection, Transducers, Diffuse optical tomography, Photoacoustic tomography, Imaging systems, Photoacoustic spectroscopy, Tissue optics

Read Abstract +

Proceedings Article | 1 March 2011 Paper

Clustered targets imaged by multizone optical tomography reconstruction method

Yan Xu, Chen Xu, Quing Zhu

Proceedings Volume 7896, 789617 (2011) https://doi.org/10.1117/12.877117

KEYWORDS: Absorption, Reconstruction algorithms, Optical properties, Optical tomography, Ultrasonography, Detection and tracking algorithms, Sensors, Computer simulations, Tumors, Breast

Read Abstract +

Proceedings Article | 18 February 2011 Paper

Investigation of a diffuse optical tomography-assisted quantitative photoacoustic tomography in reflection geometry

Chen Xu, Patrick Kumavor, Andres Aguirre, Quing Zhu

Proceedings Volume 7899, 78990U (2011) https://doi.org/10.1117/12.877074

KEYWORDS: Optical properties, Acquisition tracking and pointing, Absorption, Photoacoustic spectroscopy, Tissue optics, Photoacoustic tomography, Ultrasonography, Transducers, Blood, Optical fibers

Read Abstract +

SPIE Journal Paper | 1 May 2010 Open Access

Light shadowing effect of large breast lesions imaged by optical tomography in reflection geometry

Chen Xu, Quing Zhu

JBO, Vol. 15, Issue 03, 036003, (May 2010) https://doi.org/10.1117/12.10.1117/1.3431086

KEYWORDS: Photons, Absorption, Optical tomography, Target detection, Breast, Sensors, Ultrasonography, Optical properties, Monte Carlo methods, Cancer

Read Abstract +

DOWNLOAD PAPER

SPIE Journal Paper | 1 November 2008 Open Access

Image reconstruction method for a two-layer tissue structure accounts for chest-wall effects in breast imaging

Chen Xu, Mini Das, Yasaman Ardeshirpour, Quing Zhu

JBO, Vol. 13, Issue 06, 064029, (November 2008) https://doi.org/10.1117/12.10.1117/1.3041497

KEYWORDS: Optical properties, Absorption, Tissue optics, Image restoration, Breast, Reconstruction algorithms, Ultrasonography, Silicon, Tissues, Chest

Read Abstract +

DOWNLOAD PAPER

SPIE Journal Paper | 1 July 2008 Open Access

Optimal probe design for breast imaging using near-infrared diffused light

Chen Xu, Baohong Yuan, Quing Zhu

JBO, Vol. 13, Issue 04, 044002, (July 2008) https://doi.org/10.1117/12.10.1117/1.2966703

KEYWORDS: Absorption, Photons, Aluminum, Ultrasonography, Reflection, Breast imaging, Sensors, Tumors, Optical properties, Monte Carlo methods

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 13 February 2007 Paper

Reference selection of NIR breast imaging using perturbation approach

Chen Xu, Quing Zhu

Proceedings Volume 6434, 643415 (2007) https://doi.org/10.1117/12.700869

KEYWORDS: Monte Carlo methods, Photon transport, Near infrared, Optical properties, Tissue optics, Ultrasonography, Breast, Image restoration, Sensors, Absorption

Read Abstract +

Proceedings Article | 13 February 2007 Paper

Optimal probe design for dual-modality breast imaging

Chen Xu, Quing Zhu

Proceedings Volume 6434, 64340B (2007) https://doi.org/10.1117/12.702218

KEYWORDS: Monte Carlo methods, Ultrasonography, Optical properties, Sensors, Breast, Absorption, Image restoration, Reflection, Photon transport, Temporal resolution

Read Abstract +

Proceedings Article | 28 April 2005 Paper

Tumor angiogenesis and tumor hypoxia as diagnostic indices for differentiation of benign versus malignant breast masses

Quing Zhu, Scott Kurtzman, Edward Cronin, Mark Kane, Minming Huang, Chen Xu, NanGuang Chen, Daqing Piao, Poornima Hedge, Susan Tannenbaum, Bipin Jagjivan, Kristen Zarfos

Proceedings Volume 5693, (2005) https://doi.org/10.1117/12.592596

KEYWORDS: Tumors, Hypoxia, Breast, Diagnostics, Ultrasonography, Biopsy, Oxygen, Absorption, Tissue optics, Skin

Read Abstract +