Mr. Dierk Fricke Profile

Dierk Fricke

at Leibniz Univ Hannover

SPIE Involvement:

Author

Publications (2)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 19 February 2020 Paper

Non-contact fast Mueller matrix measurement system for investigation of bio-tissues

Dierk Fricke, Alexander Becker, Lennart Jütte, Merve Wollweber, Birgit Glasmacher, Bernhard Roth

Proceedings Volume 11211, 1121116 (2020) https://doi.org/10.1117/12.2559623

KEYWORDS: Polarization, Tissues, Polymers, Polarimetry, In vivo imaging, Structured optical fibers, Skin, Scanning electron microscopy, Liquid crystals

Read Abstract +

The orientation and concentration of structures like collagen within biological tissues can provide valuable information, for example, in skin disease diagnostics. Polarimetry lends itself for non-destructive investigation in various fields of research and development ranging from medical diagnostics to production monitoring, among others. We report on a system for polarimetric measurement of versatile targets in reflection and transmission mode. It efficiently determines the Mueller matrix (MM) of a sample under study and is also suited for in vivo applications. Generally, the Mueller matrix M_m allows to calculate the Stokes vector So of the light interacting with a sample, containing all information on its polarization properties, through S_o = M_m S_i where S_i is the Stokes vector of the illuminating light. The Mueller matrix can be derived from images taken with different polarization states of illuminating and observed light. In our setup we use liquid crystal retarders to precisely control the polarization states of the light. This enables fast measurement of the orientation of structures with high spatial resolution. In a first example, we demonstrate the capability of our system by characterizing electrospun fiber tissue implants and measuring the degree of alignment and orientation of the fibers in reflection mode. The results lead us to a deeper understanding of the signals which we expect from structures like collagen in skin. We were able to derive a correlation between the properties of the tissue structures, the parameters for production and the MM information, for the first time. This was possible by suitable decomposition of the MM into submatrices of known physical interpretation. In this work we present our latest results and discuss the next steps towards in vivo application in dermatology or tissue implant.

Proceedings Article | 7 March 2019 Presentation + Paper

Non-contact fast Mueller matrix measurement system for investigation of inflammatory skin diseases

Dierk Fricke, Stephan Maas, Lennart Jütte, Merve Wollweber, Bernhard Roth

Proceedings Volume 10863, 1086307 (2019) https://doi.org/10.1117/12.2509766

KEYWORDS: Polarization, Skin, Polarizers, Wave plates, Cameras, Collagen, Matrices, Polymethylmethacrylate

Read Abstract +

Optical systems have shown their potential in non-invasive medical diagnostics over the last years. While most imaging systems use information on wavelength or phase, e.g. OCT, in our approach we focus on the polarization properties of biotissue. We designed a Mueller matrix (MM) measurement setup for in vivo investigations on skin tissue. The MM describes the polarization-changing properties of a sample.. Thus, it is possible to calculate the MM from images taken with different polarization states of the illuminating and the observed light. For medical application, an important requirement is that the process is fast to enable in vivo measurement, avoid motion artifacts, and reduce stress for patients. In our setup, we use a combination of two polarizers and four liquid crystal retarders to quickly change between polarization states. The system is able to measure the location dependent MM of a target for different wavelengths. It is designed for measurement in reflection mode, however, upon simple modifications, it can be used in transmission mode as well. One interesting field of application is diagnostics for inflammatory skin diseases. Here, for example, changes in the structure and concentration of collagen could provide diagnostically valuable information. We evaluated our system on different skin phantoms to investigate the diagnostic advantages compared to standard approaches. In the future, our system could be part of a non-contact dermatoscopic device and provide extra information for the physician.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years