Controllable preparation of water-soluble multifunctional nanoprobes is of great significance for cancer early diagnosis. In this study, protein-modified hydrophilic copper sufide (CuS) nanotriangles with tunable absorption in the second near-infrared region are developed in the presence of halide ions. Further, DTPA-Gd3+ is conjugated on it by using the unique characteristics of the protein-protected nanotriangles. Specifically, the asobtained nanostructures are investigated as contrast agents for enhanced in vivo photoacoustic/magnetic resonance dual-modal tumor imaging. More importantly, in vitro and in vivo toxicity analysis are also performed, which show that the dual -modal nanoprobes are biocompatible for most of the cases. It is demonstrated that the novel asprepared protein-modified nanotriangles are able to work as a nanoplatform to construct dual-modal nanoprobes, which paves a new anenue for improving the photoacoustic/magnetic resonance imaging contrast in cancer detection. It should be pointed out that other functional blocks may also be linked on it, which makes it a general method to design multifunctional nanoprobes.
In this work, protein-modified hydrophilic copper sufide (CuS) nanotriangles with tunable absorption in the second near-infrared (NIR-II) region are developed, which can be served as contrast agents for enhanced in vivo photoacoustic imaging. In vitro and in vivo toxicity analysis are also performed, which show that the nanoprobes are biocompatible for most of the test cases. As a result, the nanoprones is able to pave a new avenue for improving the photoacoustic imaigng contrast and penetration depth in cancer detection. It should be pointed out that other functional blocks may also be linked on it, which makes it a general method to design multifunctional nanoprobes.
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