Dr. Chun-Hsien Wu Profile

Dr. Chun-Hsien Wu

at Univ of Texas at Austin

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Proceedings Article | 27 April 2016 Presentation

Biomedical applications of magneto-plasmonic nanoclusters (Conference Presentation)

Konstantin Sokolov, Chun-Hsien Wu, Jason Cook, Tomasz Zal, Stanislav Emelianov

Proceedings Volume 9722, 97220E (2016) https://doi.org/10.1117/12.2208719

KEYWORDS: Magnetism, Biomedical optics, Cancer, In vivo imaging, Nanoparticles, Nanotechnology, Nanostructures, Absorbance, Particles, Gold

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Perhaps one of the most intriguing aspects of nanotechnology is the ability to create multimodal and multifunctional nanostructures that can open new venues in solving challenging biomedical problems. Here, we present multimodal magneto-plasmonic nanoparticles (MPNs) with a strong red-NIR absorbance, superparamagnetic properties and a high magnetic moment in an external magnetic field. Our design is based on self-assembly of 6 nm primary particles which consist of 5 nm diameter iron-oxide cores coated with a very thin ca. 0.5 nm gold shell. The assembly results in spherical highly uniform MPNs. We developed antibody targeted MPNs to address two highly challenging applications: (i) development of real-time assays for capture, enumeration and characterization of circulating tumor cells (CTCs), and (ii) enhancement of adoptive cell immunotherapy (ACT). Our results showed that MPNs can be used for simultaneous magnetic capture and photoacoustic (PA) detection of cancer cells in whole blood with no laborious processing steps. Furthermore, we demonstrated that MPNs conjugated with anti-CD8 antibodies, which are specific for cytotoxic T cells used in ATC, label CD8+ T cells with high specificity ex vivo and in vivo. Labeled T cells can be easily manipulated by a small magnet in suspension and under flow conditions. In addition, MPNs generate high contrast in MRI and PA imaging with the potential to detect just few cells per imaging voxel. These results show that immunotargeted MPNs can be explored for simultaneous visualization and magnetic guidance of T cell subsets in vivo for cancer treatment.

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