Phase modulators in surface plasmon resonance phase-differential imaging (SPR-PI) sensing systems reported so far are
sensitive to temperature fluctuations or mechanical vibrations and thus their applications are limited. In this paper, we
propose a novel prism phase modulator (PPM) to replace a traditional modulator. The PPM consists of a parallel prism, a
rotation stage and a mirror. The PPM shows great stability in our experiment, and helps achieve high detection sensitivity
in our SPR-PI system. Moreover, the cost of our PPM is much lower than that of a traditional modulator and is thus suitable
for commercialization. A polydimethylsiloxane (PDMS) microfluidic chip is fabricated to control the flow velocity and
realize parallel detection in our experiment. Measured result of glycerine solution shows that the resolution of our SPR
biosensor array is about 9.11×10-7 refractive index unit (RIU). Real time monitoring of interaction between bovine IgG and anti-bovine IgG is also realized. The proposed PPM-based microfluidic SPR-PI biosensor array is promising for future
practical applications.
A new type of roughness silver thin films deposited on fractal surfaces of (alpha) -Al2O3 ceramics were prepared by rf- magnetron sputtering. The electrical properties of the Ag films are strongly dependant on the air pressure around the sample. When air pressure decreases to a certain value, a big jump of electrical resistant happens and the Ag thin film exhibits nonlinear I-V behavior. When releasing air into the vacuum chamber and the air pressure is raised, the film resistance restores to the primitive value and the nonlinear behavior then disappears.
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