Ms. Laura-Cristina N. Rusu Profile

Laura-Cristina N. Rusu

at Univ Medicine and Pharmacy Victor Babes Timisoara

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Publications (3)

Proceedings Article | 8 May 2015 Paper

Retractions of the gingival margins evaluated by holographic methods

Cosmin Sinescu, Meda Lavinia Negrutiu, Marius Manole, Aldo de Sabata, Laura-Cristina Rusu, Stefan Stratul, Diana Dudea, Ciprian Dughir, Virgil-Florin Duma

Proceedings Volume 9508, 95080V (2015) https://doi.org/10.1117/12.2179010

KEYWORDS: Holography, Holograms, 3D modeling, Dentistry, Teeth, Helium neon lasers, Eye models, Beam splitters, Tissues, Mirrors

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Proceedings Article | 14 January 2014 Paper

Different matrix evaluation for the bone regeneration of rats' femours using time domain optical coherence tomography

Laura-Cristina Rusu, Meda Lavinia Negrutiu, Cosmin Sinescu, Bogdan Hoinoiu, Cristian Zaharia, Lavinia Ardelean, Virgil-Florin Duma, Adrian Podoleanu

Proceedings Volume 8925, 89250V (2014) https://doi.org/10.1117/12.2045849

KEYWORDS: Bone, Interfaces, Optical coherence tomography, Curium, Confocal microscopy, Medicine, Spherical lenses, Directional couplers, Diodes, Tissue engineering

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Proceedings Article | 29 August 2013 Paper

Time domain optical coherence tomography investigation of bone matrix interface in rat femurs

Laura-Cristina Rusu, Meda-Lavinia Negruṱiu, Cosmin Sinescu, Bogdan Hoinoiu, Florin-Ionel Topala, Virgil-Florin Duma, Mihai Rominu, Adrian Podoleanu

Proceedings Volume 8914, 89141H (2013) https://doi.org/10.1117/12.2036345

KEYWORDS: Bone, Interfaces, Optical coherence tomography, Tissue engineering, Tissues, Microscopes, Confocal microscopy, Connective tissue, Polymers, Crystals

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The materials used to fabricate scaffolds for tissue engineering are derived from synthetic polymers, mainly from the polyester family, or from natural materials (e.g., collagen and chitosan). The mechanical properties and the structural properties of these materials can be tailored by adjusting the molecular weight, the crystalline state, and the ratio of monomers in the copolymers. Quality control and adjustment of the scaffold manufacturing process are essential to achieve high standard scaffolds. Most scaffolds are made from highly crystalline polymers, which inevitably result in their opaque appearance. Their 3-D opaque structure prevents the observation of internal uneven surface structures of the scaffolds under normal optical instruments, such as the traditional light microscope. The inability to easily monitor the inner structure of scaffolds as well as the interface with the old bone poses a major challenge for tissue engineering: it impedes the precise control and adjustment of the parameters that affect the cell growth in response to various mimicked culture conditions. The aim of this paper is to investigate the interface between the femur rat bone and the new bone that is obtained using a method of tissue engineering that is based on different artificial matrixes inserted in previously artificially induced defects. For this study, 15 rats were used in conformity with ethical procedures. In all the femurs a round defect was induced by drilling with a 1 mm spherical Co-Cr surgical drill. The matrixes used were Bioss and 4bone. These materials were inserted into the induced defects. The femurs were investigated at 1 week, 1 month, 2 month and three month after the surgical procedures. The interfaces were examined using Time Domain (TD) Optical Coherence Tomography (OCT) combined with Confocal Microscopy (CM). The optical configuration uses two single mode directional couplers with a superluminiscent diode as the source centered at 1300 nm. The scanning procedure is similar to that used in any CM, where the fast scanning is en-face (line rate) and the scanning in depth is much slower (at the frame rate). The results showed open interfaces due to the insufficient healing process, as well as closed interfaces due to a new bone formation inside the defect. The conclusion of this study is that TD-OCT can act as a valuable tool in the investigation of the interface between the old bone and the one that has been newly induced due to the osteoinductive process.

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