Mr. Mohamed Thaha Profile

Mohamed Thaha

at Queen Mary Univ of London

SPIE Involvement:

Author

Publications (1)

SPIE Journal Paper | 28 February 2020 Open Access

In silico and in vivo investigations using an endocavitary photoplethysmography sensor for tissue viability monitoring

Subhasri Chatterjee, Zaibaa Patel, Mohamed A. Thaha, Panayiotis Kyriacou

JBO, Vol. 25, Issue 02, 027001, (February 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.2.027001

KEYWORDS: Sensors, Tissue optics, Tissues, Photons, Monte Carlo methods, Blood, In vivo imaging, Oxygen, Photoplethysmography, Infrared radiation

Read Abstract +

Significance: Colorectal cancer is one of the major causes of cancer-related deaths worldwide. Surgical removal of the cancerous growth is the primary treatment for this disease. A colorectal cancer surgery, however, is often unsuccessful due to the anastomotic failure that may occur following the surgical incision. Prevention of an anastomotic failure requires continuous monitoring of intestinal tissue viability during and after colorectal surgery. To date, no clinical technology exists for the dynamic and continuous monitoring of the intestinal perfusion. Aim: A dual-wavelength indwelling bowel photoplethysmography (PPG) sensor for the continuous monitoring of intestinal viability was proposed and characterized through a set of in silico and in vivo investigations. Approach: The in silico investigation was based on a Monte Carlo model that was executed to quantify the variables such as penetration depth and detected intensity with respect to the sensor–tissue separations and tissue perfusion. Utilizing the simulated information, an indwelling reflectance PPG sensor was designed and tested on 20 healthy volunteers. Two sets of in vivo studies were performed using the driving current intensities 20 and 40 mA for a comparative analysis, using buccal tissue as a proxy tissue-site. Results: Both simulated and experimental results showed the efficacy of the sensor to acquire good signals through the “contact” to a “noncontact” separation of 5 mm. A very slow wavelength-dependent variation was shown in the detected intensity at the normal and hypoxic states of the tissue, whereas a decay in the intensity was found with the increasing submucosal-blood volume. The simulated detected-to-incident-photon-ratio and the experimental signal-to-noise ratio exhibited strong positive correlations, with the Pearson product-moment correlation coefficient R ranging between 0.65 and 0.87. Conclusions: The detailed feasibility analysis presented will lead to clinical trials utilizing the proposed sensor.

DOWNLOAD PAPER

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years