The purpose of this study is to obtain the relationship between skin absorbance, a rise in temperature on the skin surface, and skin burns in several mammalian species and to estimate burn risk in humans. We measured the skin absorbance of the species by diffuse reflectance spectroscopy and applied a near-infrared pulsed laser to each species on their skin. Laser irradiation raised temperature on the skin surface and caused skin burns in areas with higher absorbance, regardless of the species. We estimated the risk of skin burns for each skin type by comparing skin absorbance between humans and the mammals.
Photobiomodulation or low level laser therapy (LLLT) has been utilized in various areas of medical practice including pain relief, wound healing, and inflammation treatment. Some recent animal studies have reported that near-infrared laser irradiation to the lumbosacral nerves transcutateously relieves neuropathic pain by controlling activity of lumbosacral nerves. However, transcutaneous laser penetration to the nerves has not yet been fully elucidated. Our aim is to determine the light penetration to lumbosacral nerves when near-infrared laser was irradiated transcutateously to lumbosacral nerves. We implanted photodiodes near the lumbosacral nerves of rats and connected the photodiodes to an oscilloscope through an amplifier. Near-infrared lasers (wavelengths: 808 nm and 830 nm) were irradiated through the skin at 2, 5 and 10 W pulses (Duty 10%, 5 Hz) and outputs of photodiodes were collected. After irradiation, the depth of the photodiodes and the nerves from the skin surface were determined by micro-CT device. The result showed that the fluence rate at the lumbosacral nerves was 179±19.2 mW/cm2 and 232±20.7 mW/cm2 when the 808-nm and 830-nm laser was irradiated at 10 W respectively. These findings would be beneficial for following study of photobiomodulation.
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