Arrays of Geiger-mode avalanche photodiodes (GmAPDs) are fabricated on a new type of engineered substrates with an epitaxial layer grown on silicon-on-insulator (SOI) wafers. The SOI-based structure facilitates rapid die-level bump bonding of the GmAPD array to a CMOS readout integrated circuit (ROIC) followed by substrate removal to make a backilluminated image sensor. To fabricate the engineered substrate, a commercial substrate with a 70-nm-thick SOI layer is implanted with BF2 ions to create a p+-doped passivation layer on the light illumination surface. Subsequently, a lightly p-doped silicon layer on which the GmAPD will be fabricated is grown using a homoepitaxy process. This approach allows for the use of chip-level hybridization to CMOS, avoiding the high cost and demanding wafer flatness and smoothness requirements of wafer-scale 3D integration processes. The new process yields cleaner wafers and allows for tighter control of detector layer thickness compared to the previous process. GmAPDs fabricated on 5-μm-thick epitaxial silicon have over 70% photon detection efficiency (PDE) when 532 nm light is focused into the center 3 μm of the device with an oxide layer that remains after substrate removal. With an anti-reflective coating, the PDE can be improved.
Jet Propulsion Laboratory is developing a Europa Lander astrobiology mission concept to search for biosignatures within Europa’s subsurface. However, Europa’s rugged terrain presents a number of physical hazards for landing. MIT Lincoln Laboratory is designing a radiation-hardened real-time direct-detection LIDAR system at 532nm to aid with autonomous hazard avoidance and landing site selection for this Europa Lander concept. The detector for this system is a 2048x32 array of silicon Geiger-mode APDs and covers the required field-of-view in one dimension, removing the need for 2D stitching and enabling real-time data processing. Detector design, improvements for radiation tolerance and component characterization results are presented.
A system-level performance evaluation of Geiger-mode avalanche photodiode (GmAPD) arrays requires accurate measurement and prediction of the background rate of the device due to dark counts and other spurious detection events. Since a GmAPD detector reports only a binary value and timestamp associated with an avalanche event, dark count rates are typically measured by averaging thousands of frames to support a statistically significant measurement. For both synchronous and asynchronous detector, the Poisson distributed background rates are referenced to the time each pixel is armed. Unlike for synchronous GmAPD imagers where all the pixels are armed to an array-wide arm signal, an asynchronous pixel operates independently from its neighboring pixels; requiring the background rates to be calculated using an interarrival histogram. For both types of imagers, the background rate is typically evaluated by fitting an exponential distribution to a fixed window within a measured histogram of time intervals between detection events However, if the statistics of the background rate are insufficient – whether that is due to low population sizes, saturation, or a large dynamic range of population size across the array, the pixel, or array-wide, performance metrics may report results with varying accuracy. This paper reports on an implementation of an algorithm that evaluates GmAPD background rates based on statistical metrics rather than fixed windows. The algorithm functions by determining the appropriate integration window within the interarrival time histogram based on a per-pixel count rate set by a predetermined tolerable measurement error. The implementation of the algorithm allows us to characterize GmAPD arrays with orders of magnitude spread in background rates across the detector using common statistical parameters.
The NASA Psyche mission is set to explore an asteroid located between Mars and Jupiter with a launch date in 2022. Onboard the Psyche spacecraft is experimental demonstrator technology that will allow scientists to explore the capabilities of optical communications – a program called Deep Space Optical Communication (DSOC) led by Jet Propulsion Laboratory (JPL). DSOC seeks to improve communications performance by developing a space-based Flight Laser Transceiver (FLT) and a ground-based transceiver to enable photon-efficient communications with equipment in deep space. An integral part to this FLT system is a high-efficiency photon-counting camera (PCC) that is able to detect both the 1064nm uplink/beacon laser photons and 1550nm downlink laser photons with low background noise, and is capable of withstanding the rigors of space-travel. The paper details the characterization of several asynchronous Geiger-Mode Avalanche Photodiode (GmAPD) arrays developed by MIT Lincoln Laboratory for use in the PCC- specifically evaluating the temperature dependence of background noise, photon detection efficiency at 1064nm and 1550nm wavelengths, pixel lifetime testing, and angle of acceptance measurements. The results of this characterization are used to determine the nominal conditions for the device to operate in while in flight to maintain an efficient link with the ground-based transceiver.
KEYWORDS: Luminescence, Prototyping, Data acquisition, In vivo imaging, Signal to noise ratio, Control systems, Flow cytometry, Signal detection, Sensors, Optical spheres
Detection and enumeration of rare circulating cells in mice are important problems in many areas of preclinical biomedical research. Recently, we developed a new method termed “diffuse fluorescence flow cytometry” (DFFC) that uses diffuse photons to increase the blood sampling volume and sensitivity versus existing in vivo flow cytometry methods. In this work, we describe a new DFFC prototype with approximately an order-of-magnitude improvement in sensitivity compared to our previous work. This sensitivity improvement is enabled by a number of technical innovations, which include a method for the removal of motion artifacts (allowing interrogation of mouse hindlegs that was less optically attenuating versus the tail) and improved collection optics and signal preamplification. We validated our system first in limb mimicking optical flow phantoms with fluorescent microspheres and then in nude mice with fluorescently labeled mesenchymal stem cells at injected concentrations of 5×10 3 cells/mL . In combination, these improvements resulted in an overall cell counting sensitivity of about 1 cell/mL or better in vivo.
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