Ms. Rimante Bandzeviciute Profile

Rimante Bandzeviciute

at Vilnius Univ

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Publications (3)

SPIE Journal Paper | 28 April 2023 Open Access

Fast and label-free intraoperative discrimination of malignant pancreatic tissue by attenuated total reflection infrared spectroscopy

Rimante Bandzeviciute, Gerald Steiner, Katja Liedel, Jonas Golde, Edmund Koch, Thilo Welsch, Christoph Kahlert, Daniel E. Stange, Marius Distler, Jürgen Weitz, Justinas Ceponkus, Valdas Sablinskas, Christian Teske

JBO, Vol. 28, Issue 04, 045004, (April 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.4.045004

KEYWORDS: Tissues, Tumors, Biological samples, Infrared spectroscopy, Resection, Spectroscopy, Attenuated total reflectance, Surgery, Crystals, Germanium

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Proceedings Article | 6 March 2023 Poster + Paper

Fiber-based ATR-IR spectroscopy for an intraoperative diagnosis of normal pancreatic tissue, pancreatitis, and malignant pancreatic lesions

Rimante Bandzeviciute, Gerald Steiner, Katja Liedel, Jonas Golde, Edmund Koch, Thilo Welsch, Christoph Kahlert, Daniel Stange, Marius Distler, Jürgen Weitz, Justinas Ceponkus, Valdas Sablinskas, Christian Teske

Proceedings Volume 12368, 123680H (2023) https://doi.org/10.1117/12.2647405

KEYWORDS: Tissues, Tumors, Infrared spectroscopy, Resection, Spectroscopy, Biological samples, Surgery, Attenuated total reflectance, Education and training

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Proceedings Article | 20 February 2018 Presentation + Paper

In situ detection of cancerous kidney tissue by means of fiber ATR-FTIR spectroscopy

Valdas Sablinskas, Martynas Velicka, Milda Pucetaite, Vidita Urboniene, Justinas Ceponkus, Rimante Bandzeviciute, Feliksas Jankevicius, Tatiana Sakharova, Olga Bibikova, Gerald Steiner

Proceedings Volume 10497, 1049713 (2018) https://doi.org/10.1117/12.2289393

KEYWORDS: Tissues, Spectroscopy, Kidney, Tissue optics, Cancer, Sensors, FT-IR spectroscopy, Infrared spectroscopy, Tumors

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The crucial goal of kidney-sparing surgical resection of a malignant tumor is complete removal of the cancerous tissue. The exact border between the cancerous and normal tissues is not always possible to identify by naked eye, therefore, a supplementary intraoperative diagnosis is needed. Unfortunately, intraoperative pathology methods used nowadays are time consuming and of inadequate quality rendering not definitive diagnosis. It has recently been shown that ATR-FTIR spectroscopy can be used for fast discrimination between cancerous and normal kidney tissues by analyzing the collected spectra of the tissue touch imprint smears. Most prominent differences are obtained in the wavenumber region from 950 cm^-1 to 1250 cm^-1, where the spectral bands due to the molecular vibrations of glycogen arise in the spectra of cancerous tissue smears. Such method of detection of cancerous tissue is limited by requirement to transfer the suspected tissue from the body to the FTIR instrument and stamp it on an ATR crystal of the spectrometer. We propose a spectroscopic tool which exploits the same principle of detection of cancerous cells as mentioned above, but does not require the tissue to be transferred from the body to the spectrometer. The portable spectrometer used in this design is equipped with fiber ATR probe and a sensitive liquid nitrogen cooled MCT detector. The design of the fiber probe allows the ATR tip to be changed easily in order to use only new sterilized tips for each measurement point of the tissue. It also enables sampling multiple areas of the suspected tissue with high lateral resolution which, in turn, increases accuracy with which the marginal regions between normal and cancerous tissues can be identified. Due to the loss of optical signal in the fiber probe the spectra have lower signal-to-noise ratio than in the case of standard ATR sampling setup. However, software for the spectral analysis used with the fiber probe design is still able to distinguish between cancerous and normal tissues with high accuracy.

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