We present that dual-modal silica nanoprobes based on surface enhanced Raman spectroscopy (SERS) and fluorescence, demonstrating the several combinations of two spectroscopic signals for the noble combinatorial nanoprobes (F-SERS dot). Their synthetic procedure was introduced and dual-modal spectroscopic analyses were performed as preliminary studies. Hopefully, F-SERS dots will be one of promising and multifunctional nanoprobes for the various in vitro and in vivo biological diagnoses and screenings.
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