Mr. Weikai Xue Profile

Weikai Xue

at Lab Charles Fabry

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Publications (4)

SPIE Journal Paper | 13 August 2022 Open Access

Mirau-based line-field confocal optical coherence tomography for three-dimensional high-resolution skin imaging

Weikai Xue, Jonas Ogien, Pavel Bulkin, Anne-Lise Coutrot, Arnaud Dubois

JBO, Vol. 27, Issue 08, 086002, (August 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.8.086002

KEYWORDS: 3D image processing, Cameras, Skin, Confocal microscopy, Reflectivity, Mirrors, Mirau interferometers, Optical coherence tomography, Image resolution, 3D acquisition

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Significance: Line-field confocal optical coherence tomography (LC-OCT) is a recently introduced high-resolution imaging modality based on a combination of low-coherence optical interferometry and reflectance confocal optical microscopy with line illumination and line detection. Capable of producing three-dimensional (3D) images of the skin with cellular resolution, in vivo, LC-OCT has been mainly applied in dermatology and dermo-cosmetology. The LC-OCT devices capable of acquiring 3D images reported so far are based on a Linnik interferometer using two identical microscope objectives. In this configuration, LC-OCT cannot be designed to be a very compact and light device, and the image acquisition speed is limited.Aim: The objective of this work was to develop a more compact and lighter LC-OCT device that is capable of acquiring images faster without significant degradation of the resolution and with optimized detection sensitivity.Approach: We developed an LC-OCT device based on a Mirau interferometer using a single objective. Dynamic adjustment of the camera frequency during the depth scan is implemented, using a faster camera and a more powerful light source. The reflectivity of the beam-splitter in the Mirau interferometer was optimized to maximize the detection sensitivity. A galvanometer scanner was incorporated into the device for scanning the illumination line laterally. A stack of adjacent B-scans, constituting a 3D image, can thus be acquired.Results: The device is able to acquire and display B-scans at 17 fps. 3D images with a quasi-isotropic resolution of ∼1.5 μm (1.3, 1.9, and 1.1 μm in the x , y, and z directions, respectively) over a field of 940 μm × 600 μm × 350 μm (x × y × z) can be obtained. 3D imaging of human skin at cellular resolution, in vivo, is reported.Conclusions: The acquisition rate of the B-scans, at 17 fps, is unprecedented in LC-OCT. Compared with the conventional LC-OCT devices based on a Linnik interferometer, the reported Mirau-based LC-OCT device can acquire B-scans ∼2 times faster. With potential advantages in terms of compactness and weight, a Mirau-based device could easily be integrated into a smaller and lighter handheld probe for use by dermatologists in their daily medical practice.

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Proceedings Article | 7 March 2022 Poster + Paper

Mirau-based line-field confocal optical coherence tomography for three-dimensional high-resolution skin imaging

Weikai Xue, Jonas Ogien, Pavel Bulkin, Anne-Lise Coutrot, Arnaud Dubois

Proceedings Volume 11948, 119480G (2022) https://doi.org/10.1117/12.2608747

KEYWORDS: Skin, 3D acquisition, 3D image processing, Optical coherence tomography, Cameras, Mirrors, Objectives, Image resolution, Confocal microscopy, Mirau interferometers, Dermatology, Oncology, Optical interferometry, Optical coherence microscopy

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Proceedings Article | 30 March 2020 Presentation + Paper

Line-field confocal optical coherence tomography based on a Mirau interferometer

Weikai Xue, Jonas Ogien, Olivier Levecq, Arnaud Dubois

Proceedings Volume 11351, 113511O (2020) https://doi.org/10.1117/12.2555691

KEYWORDS: Optical coherence tomography, Mirau interferometers, Skin, Confocal microscopy, Objectives, Image resolution, Mirrors, Interferometers, Microscopes

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Proceedings Article | 22 February 2019 Paper

Line-field confocal optical coherence tomography

Jonas Ogien, Olivier Levecq, Hicham Azimani, Arthur David, Weikai Xue, David Siret, Jean-Luc Perrot, Arnaud Dubois

Proceedings Volume 10867, 108670U (2019) https://doi.org/10.1117/12.2507244

KEYWORDS: Optical coherence tomography, Confocal microscopy, Skin, Image resolution, Microscopes, Objectives, In vivo imaging, Interferometers, Light scattering

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