Neurosurgery is currently a common solution for decreasing the brain tumor burden, but it relies heavily on surgeons' experience, and intraoperative guidance still cannot be researched. To implement the real-time minimally invasive theranostics of brain tumors, the research on the intraoperative precision diagnosis and therapeutics need to be conducted. Here, we develop an optical minimally invasive theranostics system, which uses multimodal optical image including an optical coherence tomography (OCT), photoacoustic imaging (PAI) to visualize brain tumors, and uses supercontinuum laser to ablate brain tumors. The Fourier domain algorithm is employed to compute the optical attenuation coefficient (OAC) of OCT images for quantitatively identifying the brain cancerous tissue. Furthermore, we design an intelligent reseau-based optical theranostic method to integrate the intraoperative OCT imaging and laser ablation for treating brain tumors in vivo.
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