Artificial intelligence (AI)-based reconstruction is a promising method for MRI reconstruction. However, deep neural networks may exhibit instabilities in conditions that are difficult to identify with patient images. The purpose of this work is to investigate whether digital phantoms can help evaluate the performance of AI-based MRI image reconstruction. We chose AUTOMAP as an example of AI-based reconstruction method, with the network being trained with 50,000 paired patches of T1W healthy brain images and corresponding noisy k-space data. We tested the network with noisy k-space brain images, digital phantom images, and hybrid images (i.e., brain test images that contained an inserted lesion-like object). The set of brain test images was used to evaluate the global reconstruction accuracy in terms of mean squared error (MSE). The digital phantoms were designed to test image homogeneity and resolution. The hybrid images were constructed to mimic unhealthy patient for testing whether the AI reconstruction model trained with all healthy brain images would yield equal performance on abnormal brain test images. We also selected two test cases (one brain and one phantom) to quantitatively compare AI-based reconstruction and IFFT in terms of local reconstruction accuracy, which was measured by mean intensity and homogeneity of a region of interest (ROI) in a range of noise levels.
It was observed that AUTOMAP reduced noise variance on brain images within our pre-trained noise range compared to the IFFT reconstruction, but increased variance on phantoms creating inhomogeneous appearance in reconstructed phantom images. In hybrid images, similar degradation of performance was shown in the lesion-like area. Our preliminary results demonstrated that performance of the neural network was highly dependent on the training dataset. If the training data only includes healthy subjects, reconstruction of pathology regions may not be as good as healthy anatomic regions. Digital phantoms helped identify this potential generalizability issue in this AI-based MRI reconstruction.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.