KEYWORDS: Intelligence systems, Real time imaging, Optical manipulation, Microsurgery, Microfabrication, Imaging systems, Feedback control, Environmental sensing, Embedded systems, Control systems
Light-powered microrobotic swarms, excelling in manipulation efficiency and motion pattern customization, are pivotal for micro-fabrication and biomedical applications. Herein, we introduce an integrated platform capable of autonomously transporting light-powered microrobotic swarms over long distances within complex environments. The embedded real-time feedback control algorithm ensures swarm integrity and facilitates the adept navigation around unpredictable obstacles. The successful operation of both trapping- and nudging-based microrobots prove the versatile applicability of our platform.
Precise rotation of biological cells plays a pivotal role in in-situ bio-imaging and bioengineering. Here, we propose an integrated platform that enables the rotation of various ellipsoidal cells along their major and minor axes via tailoring the laser patterns and corresponding optothermal fields. Label-free in-situ three-dimensional(3D) imaging of living cells is achieved by 3D reconstruction.
Understanding the collective motion of living systems can facilitate the protection of ecosystems as well as the development of swarm robotics. To overcome the system-specific and oversimplified issues of traditional investigation methods, we propose to use our fully steerable active particles powered by localized light fields to mimic and study the collective motion in a more controllable and realistic manner. By dynamically tailoring the laser patterns that drive the colloidal particles' self-propulsion with certain interaction rules, the active particles can spontaneously form collective structures, display density-dependent responses, and show high robustness to external perturbations.
Typical optical manipulation methods operate in fluidic media. We report a novel optical manipulation technique that enables optical manipulation in a pseudo-solid media, and can immobilize particles in 3D at any prescribed locations for reconfigurable colloidal assembly and tunable light-matter interactions.
The flourishing field of light-powered micro/nanorotors provides promising strategies for manufacturing and biomedical needs. However, the torque of optical rotors typically arises from the momentum exchange with photons, which limits the geometries and materials of objects that can be rotated and requires intense laser beams with designed intensity profile and polarization. These factors inhibit the light-powered rotation of highly symmetric or isotropic targets. Herein, we developed an optothermal micro/nanorotors platform that enables the rotation of various colloids with diverse sizes, materials, and various shapes, including live cells and micro/nanoparticles with high symmetry and isotropy. The long-sought-after out-of-plane rotation has been achieved by a single plane-polarized Gaussian laser beam with an ultralow power. This simple rotor approach is foreseen to open new horizons in colloidal and life sciences by offering a non-invasive and universal manipulation.
Through innovative management of light, heat and electric field in opto-thermoplasmonic fluidics, we have developed a micro/nanorobot platform for versatile manipulation of variable synthetic micro/nanoparticles and biological cells. Five manipulation modes have been achieved and can be switched on-demand. High-throughput self-navigation of micro/nanorobots has been realized with feedback control. The multimodal and nanoscale manipulation enables in situ single-cell characterizations to achieve high-resolution 3D cellular imaging and membrane protein profiling with simple and low-power optics. With the superior functionalities and user-friendliness, our micro/nanorobot technique will become a powerful tool in colloid science, life sciences, and nanotechnology.
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