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Zexi Lin

at Fujian Normal Univ

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Proceedings Article | 31 August 2021 Paper

Quantitative assessment of anastomotic leakage in colorectal cancer by second-harmonic generation microscopy

Zexi Lin, Jiang Wei, Caihong Sun, Liqin Zheng, Zhenlin Zhan, Jun Yan, Shuangmu Zhuo

Proceedings Volume 11907, 119072I (2021) https://doi.org/10.1117/12.2603141

KEYWORDS: Tissues, Collagen, Second-harmonic generation, Colorectal cancer, Microscopy, Medical imaging, Surgery, Imaging technologies, Multiphoton microscopy, Imaging systems

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Surgical resection of colorectal cancer is currently the most effective treatment. However, anastomotic leakage (AL), as one of the most severe complications after colorectal cancer surgery, has seriously threatened patients’ quality of life and prognosis. Collagen fibers play an essential role in AL. This study explores the correlation between collagen fiber and AL, which can improve the understanding of this complication and help clinicians judge the prognosis and treatment of patients. Second-harmonic generation (SHG) imaging technology is a non-invasive, label-free, and up-and-coming new technology. It has been proven to be a vital tool for visualizing collagen fibers. In this work, SHG imaging technology is used to perform high-resolution, label-free imaging on paraffin-embedded specimens of AL; collagen is excited by 810nm light, and SHG signals are detected in the range of 395-415nm. Combined with a specific image processing method, select regions of interest of the same size to obtain the collagen fiber characteristics used to distinguish an AL from normal tissues. The study results showed a significant difference in the collagen fiber characteristics between the AL tissue and the normal tissue (p<0.05). In short, the combination of SHG imaging technology and quantitative image processing methods is expected to provide a new method for the effective and rapid identification of AL and also lay the foundation for individualized prediction of AL in patients with colorectal cancer. This research has crucial academic significance and clinical application prospects.

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