Monitoring cerebral blood flow with superconducting nanowire detectors

Maria A. Franceschini; Nisan Ozana; Mitchell B. Robinson; Megan H. Blackwell; Stefan A. Carp; Marco Renna

doi:10.1117/12.2622923

30 May 2022 Monitoring cerebral blood flow with superconducting nanowire detectors

Maria A. Franceschini, Nisan Ozana, Mitchell B. Robinson, Megan H. Blackwell, Stefan A. Carp, Marco Renna

Proceedings Volume PC12089, Advanced Photon Counting Techniques XVI; PC1208907 (2022) https://doi.org/10.1117/12.2622923
Event: SPIE Defense + Commercial Sensing, 2022, Orlando, Florida, United States

Abstract

Diffuse correlation spectroscopy (DCS) is an emerging near infrared spectroscopy modality able to measure cerebral blood flow (CBF) non-invasively and continuously in humans. We have reported a limited applicability in adults due to the significant extracerebral tissue thickness and the low signal-to-noise ratio (SNR) of the measurements. Improvements to DCS brain sensitivity and SNR can be achieved by operating DCS at 1064 and using superconducting nanowire single-photon detectors (SNSPDs). Initial human results show a 16-fold improvement in SNR and 20% improvement in depth sensitivity. This allows us to resolve changes in CBF in adult subjects more robustly and accurately than was previously achievable.

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Maria A. Franceschini, Nisan Ozana, Mitchell B. Robinson, Megan H. Blackwell, Stefan A. Carp, and Marco Renna "Monitoring cerebral blood flow with superconducting nanowire detectors", Proc. SPIE PC12089, Advanced Photon Counting Techniques XVI, PC1208907 (30 May 2022); https://doi.org/10.1117/12.2622923

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KEYWORDS

Cerebral blood flow

Nanowires

Sensors

Superconductors

Signal to noise ratio

Near infrared spectroscopy

Photon counting

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