Fullerene C60 and graphene photosensibiles for photodynamic virus inactivation

I. Belousova; A. Hvorostovsky; V. Kiselev; V. Zarubaev; O. Kiselev; L. Piotrovsky; P. Anfimov; T. Krisko; T. Muraviova; V. Rylkov; A. Starodubzev; A. Sirotkin; A. Grishkanich; I. Kudashev; A. Kancer; M. Kustikova; E. Bykovskaya; A. Mayurova; A. Stupnikov; J. Ruzankina; M. Afanasyev; N. Lukyanov; D. Redka; N. Paklinov

doi:10.1117/12.2294593

13 February 2018 Fullerene C60 and graphene photosensibiles for photodynamic virus inactivation

I. Belousova, A. Hvorostovsky, V. Kiselev, V. Zarubaev, O. Kiselev, L. Piotrovsky, P. Anfimov, T. Krisko, T. Muraviova, V. Rylkov, A. Starodubzev, A. Sirotkin, A. Grishkanich, I. Kudashev, A. Kancer, M. Kustikova, E. Bykovskaya, A. Mayurova, A. Stupnikov, J. Ruzankina, M. Afanasyev, N. Lukyanov, D. Redka, N. Paklinov

Author Affiliations +

Proceedings Volume 10492, Optical Interactions with Tissue and Cells XXIX; 1049215 (2018) https://doi.org/10.1117/12.2294593
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

A solid-phase photosensitizer based on aggregated C60 fullerene and graphene oxide for photodynamic inactivation of pathogens in biological fluids was studied. The most promising technologies of inactivation include the photodynamic effect, which consists in the inactivation of infectious agents by active oxygen forms (including singlet oxygen), formed when light is activated by the photosensitizer introduced into the plasma. Research shows features of solid-phase systems based on graphene and fullerene C60 oxide, which is a combination of an effective inactivating pathogens (for example, influenza viruses) reactive oxygen species formed upon irradiation of the photosensitizer in aqueous and biological fluids, a high photostability fullerene coatings and the possibility of full recovery photosensitizer from the biological environment after the photodynamic action.

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I. Belousova, A. Hvorostovsky, V. Kiselev, V. Zarubaev, O. Kiselev, L. Piotrovsky, P. Anfimov, T. Krisko, T. Muraviova, V. Rylkov, A. Starodubzev, A. Sirotkin, A. Grishkanich, I. Kudashev, A. Kancer, M. Kustikova, E. Bykovskaya, A. Mayurova, A. Stupnikov, J. Ruzankina, M. Afanasyev, N. Lukyanov, D. Redka, and N. Paklinov "Fullerene C60 and graphene photosensibiles for photodynamic virus inactivation", Proc. SPIE 10492, Optical Interactions with Tissue and Cells XXIX, 1049215 (13 February 2018); https://doi.org/10.1117/12.2294593

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