Two-dimensional auto-correlation analysis and Fourier-transform analysis of second-harmonic-generation image for quantitative analysis of collagen fiber in human facial skin

Yuki Ogura; Yuji Tanaka; Eiji Hase; Toyonobu Yamashita; Takeshi Yasui

doi:10.1117/12.2289226

23 February 2018 Two-dimensional auto-correlation analysis and Fourier-transform analysis of second-harmonic-generation image for quantitative analysis of collagen fiber in human facial skin

Yuki Ogura, Yuji Tanaka, Eiji Hase, Toyonobu Yamashita, Takeshi Yasui

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Proceedings Volume 10498, Multiphoton Microscopy in the Biomedical Sciences XVIII; 104982M (2018) https://doi.org/10.1117/12.2289226
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

We compare two-dimensional auto-correlation (2D-AC) analysis and two-dimensional Fourier transform (2D-FT) for evaluation of age-dependent structural change of facial dermal collagen fibers caused by intrinsic aging and extrinsic photo-aging. The age-dependent structural change of collagen fibers for female subjects’ cheek skin in their 20s, 40s, and 60s were more noticeably reflected in 2D-AC analysis than in 2D-FT analysis. Furthermore, 2D-AC analysis indicated significantly higher correlation with the skin elasticity measured by Cutometer® than 2D-AC analysis. 2D-AC analysis of SHG image has a high potential for quantitative evaluation of not only age-dependent structural change of collagen fibers but also skin elasticity.

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Yuki Ogura, Yuji Tanaka, Eiji Hase, Toyonobu Yamashita, and Takeshi Yasui "Two-dimensional auto-correlation analysis and Fourier-transform analysis of second-harmonic-generation image for quantitative analysis of collagen fiber in human facial skin", Proc. SPIE 10498, Multiphoton Microscopy in the Biomedical Sciences XVIII, 104982M (23 February 2018); https://doi.org/10.1117/12.2289226

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KEYWORDS

Skin

Collagen

Second-harmonic generation

Structured optical fibers

Image analysis

Quantitative analysis

Microscopy

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