CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 10864 > Article
Presentation
4 March 2019 Stimulation and repair of peripheral nerves using a bioadhesive graft-antenna (Conference Presentation)
Antonio Lauto, Ashour Sliow, Zhi Ma, Gaetano D. Gargiulo, David Mahns, Damia Mawad, Paul Breen, Marcus Stoodley, Jessica Houang, Giuseppe Tettamanzi, John W. Morley, Leonardo Longo, Rhiannon Kuchel
Author Affiliations +
Proceedings Volume 10864, Clinical and Translational Neurophotonics 2019; 1086405 (2019) https://doi.org/10.1117/12.2508255
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
Peripheral nerve injuries are difficult to treat because axon regeneration is limited and functional recovery is often unsatisfactory in patients. Brief electrical stimulation of injured nerves is emerging as a new promising therapy that can relieve pain or induce better axon regeneration and functional recovery than untreated nerves. In this study, we report an innovative wireless and biocompatible stimulator that is also a scaffold for injured nerves when an autograft is applied to bridge a gap in rat sciatic nerves. We have named this device “graft-antenna” to highlight the double functionality of the implant. The scaffold is made of chitosan and incorporates a gold loop antenna (diameter ~1.3 mm, thickness ~70 nm) powered wirelessly by a transcranial magnetic stimulator (TMS). The device is bonded to tissue non-invasively and without sutures, exploiting the photo-adhesion properties of the chitosan scaffold. The stimulator did not migrate after implantation on healthy sciatic nerves in rats and was able to trigger a steady compound muscle action potential for 12 weeks (CMAP ~1.3 mV). No CMAP was elicited by the TMS when the wireless stimulator was not implanted on nerves. Axon regeneration was facilitated in sciatic nerves that were grafted with the graft-antenna and stimulated for 1 hour, once a week (magnetic field magnitude~0.72 T, pulse duration ~350 μs, repetition rate=1 pulse/sec). Eight weeks post-operatively, myelinated axon count, CMAP and nerve conduction velocity were statistically higher in the graft-antenna group (n=5) than in nerves grafted with the chitosan scaffold without antenna.
Conference Presentation
© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Antonio Lauto, Ashour Sliow, Zhi Ma, Gaetano D. Gargiulo, David Mahns, Damia Mawad, Paul Breen, Marcus Stoodley, Jessica Houang, Giuseppe Tettamanzi, John W. Morley, Leonardo Longo, and Rhiannon Kuchel "Stimulation and repair of peripheral nerves using a bioadhesive graft-antenna (Conference Presentation)", Proc. SPIE 10864, Clinical and Translational Neurophotonics 2019, 1086405 (4 March 2019); https://doi.org/10.1117/12.2508255
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Axons
Antennas
Magnetism
Nerve
Action potentials
Bridges
Gold
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top