Multi-scale and -mode sensorless adaptive optics OCT for in vivo human retinal imaging (Conference Presentation)

JiHoon Kwon; Destiny Hsu; Myeong Jin Ju; Daniel Wahl; Yifan Jian; Marinko V. Sarunic

doi:10.1117/12.2510995

4 March 2019 Multi-scale and -mode sensorless adaptive optics OCT for in vivo human retinal imaging (Conference Presentation)

JiHoon Kwon, Destiny Hsu, Myeong Jin Ju, Daniel Wahl, Yifan Jian, Marinko V. Sarunic

Author Affiliations +

Proceedings Volume 10867, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII; 1086721 (2019) https://doi.org/10.1117/12.2510995
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

In this study we describe our novel Multi-Scale and multi-Mode Sensorless Adaptive Optics OCT system (MSM-SAO-OCT). Our system expands upon our previously reported work by introducing a zoomable collimator, phase calibration interferometer, and polarization diversity detection module. By using a zoomable collimator into the system setup, we allow an adjustable probing beam diameter without the need to change the optical setup, permitting imaging with both low and high lateral resolution (18 µm – 6 µm) at various Fields of View (FOV) within diffraction limited resolution. By employing SAO optimization algorithm, different morphological structures and microvasculature in a retina were clearly visualized after wavefront aberration correction with dual deformable optical elements – Variable Focus Lens (VFL) for defocus and a Multi-Actuator Adaptive Lens (MAL) for two astigmatisms. For retinal vasculature imaging, MSM-SAO-OCT system generates flow-specific contrast as measuring amplitude of complex variance from the multiple OCT B-scans from the same transverse location after stabilizing OCT signals in a phase using a static interference signal from phase calibration interferometer. In addition, the use of polarization diversity detection allows to create Degree Of Polarization Uniformity (DOPU) contrast using for visualization of the Retinal Pigment Epithelium (RPE) with its inherent tissue characteristic (polarization scrambling). In order to demonstrate functionality and clinical utility of the MSM-SAO-OCT system, in vivo human retinal imaging was performed on research subjects, and imaging results are presented and discussed.

Conference Presentation

Citation Download Citation

JiHoon Kwon, Destiny Hsu, Myeong Jin Ju, Daniel Wahl, Yifan Jian, and Marinko V. Sarunic "Multi-scale and -mode sensorless adaptive optics OCT for in vivo human retinal imaging (Conference Presentation)", Proc. SPIE 10867, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 1086721 (4 March 2019); https://doi.org/10.1117/12.2510995

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KEYWORDS

Optical coherence tomography

Imaging systems

Retinal scanning

Adaptive optics

In vivo imaging

Sensors

Polarization

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