Multiple reactions monitoring for determinating methadone and its metabolite

Ruxandra Populeanu; Radu Alexandru Macovei; Marian Vlădescu; Genica Caragea; Ruxandra Avram; Mihai Ionică

doi:10.1117/12.2323612

31 December 2018 Multiple reactions monitoring for determinating methadone and its metabolite

Ruxandra Populeanu, Radu Alexandru Macovei, Marian Vlădescu, Genica Caragea, Ruxandra Avram, Mihai Ionică

Proceedings Volume 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX; 109773A (2018) https://doi.org/10.1117/12.2323612
Event: Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies IX, 2018, Constanta, Romania

Abstract

Methadone is an opioid used in medicine as an analgesic and antidependent maintenance in opioid dependent patients. It is used in the substitution treatment for heroin or other opiates. Methadone belongs to the category of special drugs with a very high potential for dependence and a low lethal dose [1]. Mass spectrometry is an optoelectronic method for determining organic substances by comparing their mass spectrum with mass spectra found in the NIST, Wiley, PMW, and other mass spectrum libraries. In the case of biological products, substances of interest, biotic or xenobiotics may be "hidden" from the noise of the analyzed matrix. A method was developed on a gas chromatograph coupled with a Varian Mass Spectrometer (GC-MS) [2, 3]. The authors presented two methods of increasing sensitivity and signal / noise ratio for the identification of methadone and its metabolites by dissociating ion-specific parent ion for methadone and its metabolites to obtain an MS/MS spectrum.

Citation Download Citation

Ruxandra Populeanu, Radu Alexandru Macovei, Marian Vlădescu, Genica Caragea, Ruxandra Avram, and Mihai Ionică "Multiple reactions monitoring for determinating methadone and its metabolite", Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 109773A (31 December 2018); https://doi.org/10.1117/12.2323612

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