Dr. Marian Vladescu is Associate Professor / Reader at “Politehnica” University of Bucharest, Faculty of Electronics, Telecommunications and Information Technology, currently Head of Department of ElectronicTechnology and Reliability, and Research Scientist at Optoelectronics Research Center, his area of expertise being in optoelectronics (devices, circuits and sensors). He received B.Sc. & M.Sc. degrees in applied electronics from “Politehnica” University of Bucharest and Ph.D. degree in optoelectronics, with Cum Laude grade, from the same university. He has more than 35 years of experience in electronic design, working 3 years in R&D for laser telemetry, 6 years in R&D for power supplies, 9 years in implementing digital communication technologies (SDH, ATM, xDSL, GPON), 5 years in R&D for biometric systems, and more than 5 years in R&D for omnidirectional vision systems. He has been Invited Lecturer at “Politehnica” University of Bucharest for 21 years, then Senior Lecturer for 5 years, and he authored more than 50 scientific papers (author or co-author). He is holding a patent (as co-author), invention that received the silver medal at International Exhibition of Inventions in Geneva. He coordinates two laboratories at the "Research Center for Advanced Materials, Products and Processes" at University Politehnica of Bucharest, Lab #1: Optoelectronics, Dielectric and Piezoelectric Materials and Lab #2: SAW microsensors and Components and Systems for Optical Communications (including Quantum Technologies).
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Cocaine has major toxic effects on the body. Treatment of cocaine poisoning is complex. The main sales are those that can lead to patient death. For the proper treatment of any inoculation, it is necessary to identify the xenobiotic that generated it. The presence of metabolites, in the case of cocaine - ethylbenzoylcogene (EBE), provides information on the time of administration of the xenobiotic.
Gas chromatography or liquid chromatography coupled with mass spectrometry is an optoelectronic method that can identify the presence of cocaine and / or EBE from biological samples. In order to increase the sensitivity of the method, a special mass metrology technique - MS/MS can be used [4, 5].
The novelty is that this system, as an evolved autonomous emergency brake system, parking aid and stop and go system has been designed and built as standalone system, on its own, that is, regardless of the other systems a vehicle can have. This system can interact with practically any systems at any level and can be adapted to virtually any existing brake system.
The MRM method is performed with a varying concentration gradient of between 10% and 65% [3] over a 9 minute acquisition time at a constant flow rate of 0.3 ml / minute. The gradient increases from 10% to 40% in the first two minutes, then increases from 40% to 65% over the next 3 minutes. The 65% concentration remains for the next 4 minutes.
The method presented in the paper will be based on liquid chromatography with a mass spectrometer detector (LCMS/ MS). The paper aims to obtain, using the developed method, the mass spectra of synthetic cannabinoids and their metabolites. The mass spectrum represents the relative abundance of ions resulting from an ionization process of a family of molecules. This is a unique feature for each compound, which allows identification of a substance from a matrix of unknown substances [3].
What is new in this system, as an evolved sensory fusion system, is that the entire system has been designed and built according with specific requests of a real life situation, as standalone system, on its own, that is, regardless of the other systems a production area / shop floor / equipment a building can have. This system can interact with practically any systems at any level and can be adapted to virtually any existing building system.
In order to avoid accidental contamination of the population with xenobiotics pesticides, the European Union issued "Regulation (EU) No 915/2010 on ensuring compliance with maximum permitted levels of pesticide residues in and on foodstuffs of plant and animal origin and assessment of consumer exposure to these residues [3]. The list includes 175 pesticides, of which 36 (20%) are OPs.
Optoelectronics has made an important contribution to understanding the life and the impact of xenobiotics on it. The development of spectrophotometry or spectrometry techniques in the field of UV-VIS-IR and mass spectrometry allowed scientists in the field of bio-science to better understand the mysteries of life or to characterize the impact of some elements or chemicals on it [4].
It’s presented an optoelectronic gas chromatographic method coupled with mass spectrometry is used to determine OPs that may be present in control sample (standard mixture) for food, soil or water.
Its use in auto catalysts results in environmental contamination of crowded cities and high-traffic roads. In medicine, Pt is used as a cytostatic drug. Specific platinum complexes, especially cis-diamminedichloroplatinum (II) (cisplatin), Cis-[oxalate (trans-1-1,2- diaminocyclohexane)] platinum(II) (oxaliplatin) and cis-diammine (1,1- cyclobutanedicarboxylato) platinum(II) (carboplatin), used in therapeutic practice [1,2]. Determination of the Pt concentration in biological samples provides medical personnel with useful information on the efficacy of the cytostatic treatment. An optoelectronic method for determining the concentration of Pt in urine, blood and hair samples collected from patients undergoing cytostatic treatment with platinum-based products is presented. To determine the concentration of Pt in biological products was used: Atomic Absorption Spectrometer model AAS-880, Atomization in the graphite furnace model GT 100, Programable Sample Dispenser PSD - Varian. Platinum concentrations of biological samples collected from platinum, based cytotoxic patients are presented. The presented method can be used to monitor platinumbased chemotherapy with platinum compounds. Graphite Furnace Atomic Absorption Spectroscopy (GF-AAS) method presented is sensitive, reproducible, and relatively easy to apply with an acceptable cost.
Papaverine is used to treat gastrointestinal tract spasms, bile ducts, ureters as a cerebral and coronary vasodilator, subarachnoid hemorrhage [3] and a coronary artery bypass [4]. Papaverine is used as a smooth muscle relaxant in microsurgery if it is applied directly to blood vessels. In the treatment of erectile dysfunction, a papaverine gel has recently been used [5]. Also, in combination with other drugs, it is commonly used in cryopreservation of blood vessels [6, 7].
Papaverine is a direct relaxing smooth muscle, which is attributed to its ability to inhibit phosphodiesterase. It can be administered for peripheral cerebral and coronary circulation. It can also be used for vascular disorders, for gastrointestinal disorders as an antispasmodic and against cough. However, its use for the latest recommendations should be regarded with caution [8].
For these reasons, the determination of papaverine in urine samples is very important [2]. Identification is preferably by GC-MS or HPLC-MS chromatographic techniques [9].
To determine the presence of antidepressants in biological products, it has been used a system HPLC-MS (High Performance Liquid Chromatography – Mass Spectrometry) Varian 12001. The system is equipped with APCI (Atmospheric Pressure Chemical Ionization) or ESI (ElectroSpray Ionization) interface. To find antidepressants in unknown samples is necessary to recognize them after mass spectrum. Because the mass spectrum it is dependent on obtaining private parameters work of HPLC-MS system, and control interfaces, the mass spectra library was filled with the mass spectra of all approved antidepressants in Romania. The paper shows the mass spectra obtained in the HPLCMS system.
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