Angle-resolved low-coherence interferometry (a/LCI) is an optical technique which uses inverse models of light scattering to predict the size and density of cell nuclei, a significant biomarker of precancer. In recent years, substantial progress has occurred in a/LCI technology, particularly in novel instrumentation for the detection of dysplasia in the cervix and the esophagus. This abstract summarizes recent developments in a/LCI, with a focus on developments over the previous four years. Clinical studies in the cervix, novel optical instrumentation addressing the cervix and esophagus, and novel applications related to Alzheimer’s disease are discussed.
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