Mr. Michael Crose Profile

Michael Crose

at Lumedica Inc

SPIE Involvement:

Author

Publications (5)

Proceedings Article | 10 March 2020 Presentation

Progress in angle-resolved low-coherence interferometry for real-time detection of epithelial dysplasia (Conference Presentation)

Zachary Steelman, Derek Ho, Yang Zhao, Haoran Zhang, Evan Jelly, Ge Song, Wesley Kendall, Michael Crose, Brian Cox, Kengyeh Chu, Adam Wax

Proceedings Volume 11253, 1125302 (2020) https://doi.org/10.1117/12.2545173

KEYWORDS: Interferometry, Light scattering, Cervix, Esophagus, Optical coherence tomography, In vivo imaging, Endoscopy, Scattering, Multimode fibers, Computer architecture

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Proceedings Article | 13 March 2019 Presentation

First clinical application of low cost portable OCT system (Conference Presentation)

Ge Song, Sanghoon Kim, Michael Crose, Brian Cox, Evan Jelly, J. Niklas Ulrich, Adam Wax

Proceedings Volume 10858, 108580E (2019) https://doi.org/10.1117/12.2507936

KEYWORDS: Optical coherence tomography, Gold, Ophthalmology, Eye, Image acquisition, Interfaces, Retinal scanning, Imaging systems

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Proceedings Article | 4 March 2019 Presentation

Esophageal OCT using endoscope-coupled paddle probe (Conference Presentation)

Yang Zhao, Kengyeh Chu, Michael Crose, Yaa Ofori-Marfoh, Holly Cirri, Nicholas Shaheen, Adam Wax

Proceedings Volume 10854, 108540K (2019) https://doi.org/10.1117/12.2510237

KEYWORDS: Optical coherence tomography, Endoscopes, Endoscopy, 3D acquisition, Fiber optics, Video, Diagnostics, Esophagus, Visualization, Silicon

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Proceedings Article | 14 March 2018 Presentation

In vivo mapping of the cervical epithelium using multiplexed low-coherence interferometry (Conference Presentation)

Kengyeh Chu, Derek Ho, Michael Crose, Chenfei Hu, Michael DeSoto, Jennifer Peters, Amy Murtha, Daryl Wieland, Michael Zinaman, Adam Wax

Proceedings Volume 10472, 1047206 (2018) https://doi.org/10.1117/12.2290882

KEYWORDS: Interferometry, In vivo imaging, Multiplexing, Cervix, Endoscopy, Cervical cancer, Interferometers, Fiber optics, Cell biology, Optical testing

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The early detection of cervical dysplasia enables early treatment, a critical factor in cancer prevention. In the United States, cervical cancer screening is age-based and includes cervical cytology with human papilloma virus (HPV) testing with referral to colposcopy for abnormal results. Colposcopy is used to visualize changes in the appearance of the transformation zone to direct biopsies which can confirm a diagnosis of dysplasia or cancer. Directed biopsies can be limited in detection of abnormalities because they represent a small area of the transformation zone and can be limited by provider expertise. Additionally, biopsies contribute to patient discomfort and anxiety awaiting for results. We recently reported the first in vivo cervical data from angle-resolved low-coherence interferometry (a/LCI), an optical technique that measures nuclear size as a biomarker for dysplasia, which is well-suited for screening due to its high sensitivity and specificity and its non-invasive utilization. However, in order to target the single-point measurements of the a/LCI instrument, we aimed to construct a probe capable of mapping the cervical epithelium to identify the transformation zone between the ectocervical and endocervical epithelia, the location at which dysplasia is most likely to develop. We termed this complementary technology multiplexed low-coherence interferometer (m/LCI). Thirty-six parallel fiber-optic interferometers were constructed to obtain optical depth profiles using spectral-domain LCI. Light from each channel is delivered to the cervix via a 6x6 fiber-optic bundle and a custom endoscopic probe. The depth-profile from each optical channel enables the identification of the ectocervix and endocervix. A pilot study at Duke University (n=5) was followed by an ongoing clinical study at New York City Health + Hospitals/Jacobi (Bronx, New York) (current n=20, target n=50). We present the results from these first studies to demonstrate the feasibility of m/LCI as a means of identifying the transformation zone for screening of dysplasia.

Proceedings Article | 19 April 2017 Presentation

Novel multiplexed low coherence interferometry endoscopic probe for analyzing the cervical epithelium in vivo (Conference Presentation)

Derek Ho, Kengyeh Chu, Michael Crose, Michael Desoto, Jennifer Peters, Amy Murtha, Adam Wax

Proceedings Volume 10043, 1004304 (2017) https://doi.org/10.1117/12.2252607

KEYWORDS: Mach-Zehnder interferometers, Multiplexing, Interferometry, Endoscopy, In vivo imaging, Cervical cancer, Analytical research, Light scattering, Cervix, Algorithm development

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