Multispectral fluorescence lifetime imaging system with Si avalanche photodetector: a better platform for clinical application

Xiangnan Zhou; Julien Bec; Diego Yankelevich; Laura Marcu

doi:10.1117/12.2579121

5 March 2021 Multispectral fluorescence lifetime imaging system with Si avalanche photodetector: a better platform for clinical application

Xiangnan Zhou, Julien Bec, Diego Yankelevich, Laura Marcu

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Proceedings Volume 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX; 116310E (2021) https://doi.org/10.1117/12.2579121
Event: SPIE BiOS, 2021, Online Only

Abstract

We report the design, development, and characterization of the first multispectral fluorescence lifetime imaging platform designed for clinical application based on avalanche photodiodes (APD). Consistent and accurate measurement of fluorescence lifetimes is achieved. Fast dynamic gain adjustment via APD bias modulation is implemented independently for each spectral channel, maximizing photon economy and greatly improving signal quality. Compared to conventional MCP-PMT based systems, the new platform presents 5-fold reduction of lifetime measurement variability under identical experiment conditions. This improved photon economy leads to 35 times faster coverage of imaging field in clinical practice with identical tissue exposure, making the new platform better suited for clinical application.

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Xiangnan Zhou, Julien Bec, Diego Yankelevich, and Laura Marcu "Multispectral fluorescence lifetime imaging system with Si avalanche photodetector: a better platform for clinical application", Proc. SPIE 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX, 116310E (5 March 2021); https://doi.org/10.1117/12.2579121

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KEYWORDS

Imaging systems

Avalanche photodetectors

Fluorescence lifetime imaging

Multispectral imaging

Silicon

Luminescence

Tissues

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