Prof. Laura Marcu Profile

Prof. Laura Marcu

Professor at Univ of California Davis

SPIE Involvement:

Conference Chair | Editorial Board Member: Biophotonics Discovery | Editor | Author | Special Event Speaker

Publications (116)

Proceedings Article | 13 March 2024 Presentation

Investigating fluorescence lifetime signatures for normal tissue adjacent to cancer in oropharyngeal squamous cell carcinomas

Katjana Ehrlich, Kelsey Hadfield, Mohamed Hassan, Brent Weyers, Xiangnan Zhou, Julien Bec, Dorina Gui, Arnaud Bewley, Marianne Abouyared, D. Gregory Farwell, Andrew Birkeland, Laura Marcu, Lisanne Kraft

Proceedings Volume PC12818, (2024) https://doi.org/10.1117/12.3003488

KEYWORDS: Tissues, Fluorescence, Cancer, Neck, Head, Tumors, Resection, Collagen, Windows, Time resolved spectroscopy

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Proceedings Article | 13 March 2024 Presentation

Optical biopsy of brain tumors using fluorescence lifetime imaging (FLIm)

Orin Bloch, Silvia Noble Anbunesan, Alba Alfonso Garcia, Julien Bec, Mohamed Hassan, Lisanne Kraft, Matthew Bobinski, Han Sung Lee, Lee-Way Jin, Laura Marcu

Proceedings Volume PC12831, PC1283101 (2024) https://doi.org/10.1117/12.3001898

KEYWORDS: Biopsy, Brain, Tumors, Neuroimaging, Fluorescence lifetime imaging, Tissues, Magnetic resonance imaging, Brain tissue, Windows, Tissue optics

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Proceedings Article | 13 March 2024 Presentation

Detecting infiltrative edges of brain tumors using label-free intraoperative FLIm

Mohamed Hassan, Silvia Noble Anbunesan, Alba Alfonso García, Matthew Bobinski, Han Lee, Lee-Way Jin, Orin Bloch, Laura Marcu

Proceedings Volume PC12831, PC1283102 (2024) https://doi.org/10.1117/12.3003609

KEYWORDS: Tumors, Cancer detection, Brain, Edge detection, Tissues, Surgery, Resection, Receivers, Performance modeling, Neuroimaging

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Proceedings Article | 13 March 2024 Presentation

Demonstration of a combined multispectral FLIm/polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions

Julien Bec, Xiangnan Zhou, Martin Villiger, Brett Bouma, Laura Marcu

Proceedings Volume 12819, 1281908 (2024) https://doi.org/10.1117/12.3003560

KEYWORDS: Optical coherence tomography, Atherosclerosis, Imaging systems, Polarization, Imaging devices, Visualization, Tissues, Pathogens, Natural surfaces, Modulation

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Proceedings Article | 13 March 2024 Presentation

Assessing in vivo label-free fluorescence lifetime Imaging sensitivity to low-grade colon inflammation

Alba Alfonso García, Jee-Yon Lee, Alex Condon, Julien Bec, Xiangnan Zhou, Andreas Baumler, Laura Marcu

Proceedings Volume PC12822, PC1282206 (2024) https://doi.org/10.1117/12.3002008

KEYWORDS: Colon, Inflammation, In vivo imaging, Fluorescence lifetime imaging, Tissues, Mode conditioning cables, Switches, Reliability, Portability, Micro optics

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Proceedings Article | 13 March 2024 Presentation

Mesoscopic FLIm for detection of residual cancer in transoral robotic surgery

Mohamed Hassan, Brent Weyers, Julien Bec, Jinyi Qi, Dorina Gui, Arnaud Bewley, Marianne Abouyared, Andrew Birkeland, Laura Marcu

Proceedings Volume PC12818, (2024) https://doi.org/10.1117/12.3003627

KEYWORDS: Cancer, Tumor growth modeling, Robotic surgery, Data modeling, Cancer detection, Tumors, Tissues, Surgery, Cross validation, Resection

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Proceedings Article | 12 March 2024 Presentation + Paper

On-chip hyperspectral detectors for fluorescence lifetime imaging

Ahasan Ahamed, Amita Rawat, Lisa McPhillips, M. Saif Islam, Laura Marcu

Proceedings Volume 12853, 1285304 (2024) https://doi.org/10.1117/12.3002476

KEYWORDS: Sensors, Fluorescence lifetime imaging, Avalanche photodetectors, External quantum efficiency, Fluorescence, Tissues, Emission wavelengths, Quantum detection, Photonic nanostructures, Fluorescence spectroscopy

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Fluorescence Lifetime Imaging (FLIM) is a powerful technique that measures the decay time of fluorophores present in tissue samples alluding to their constituent molecules. FLIM has gained popularity in biomedical imaging for applications such as detecting cancerous tumors, surgical guidance, etc. However, conventional FLIM systems are limited by a reduced number of spectral bands and long acquisition time. Moreover, the large footprint, complexity, and cost of the instrumentation make it difficult for clinical applications. In this paper, we demonstrate a reconstruction-based hyperspectral detector that can resolve decay time and intensities in broad spectral ranges while providing high sensitivity, high gain, and fast response time. The hyperspectral detector is comprised of an array of efficient, ultrafast avalanche photodetectors integrated with nanophotonic structures. We utilize different nanostructures in the detectors to modulate light-matter interactions in spectral channels. This allows us to computationally reconstruct the spectral profile of the incoming fluorescence spectrum without the need for additional filters or dispersive optics. Also, the nanophotonic structures enhance efficiency (by a factor of 2 to 10 over different wavelengths) while providing fast response time. An innovative detector design has been employed to reduce the breakdown of the avalanche photodetectors to -7.8V while maintaining high gain (~50) across the spectral range. Therefore, enabling low light detection with a high signal-to-noise ratio for FLIM applications. Added spectral channels would provide valuable information about tissue materials, morphology, and disease diagnosis. Such innovative hyperspectral sensors can now be integrated on-chip capable of miniaturizing the FLIM system and making it a commercially viable tool for clinical use. This technology has the potential to revolutionize the current FLIM system with improved detection capabilities opening doors for new horizons.

SPIE Journal Paper | 13 May 2023 Open Access

Intraoperative molecular imaging: 3rd biennial clinical trials update

Patrick Bou-Samra, Najib Muhammad, Austin Chang, Ritesh Karsalia, Feredun Azari, Gregory Kennedy, Walter Stummer, Janos Tanyi, Linda Martin, Alexander Vahrmeijer, Barbara Smith, Eben Rosenthal, Patrick Wagner, David Rice, Amy Lee, Hafeez Abdelhafeez, Marcus M. Malek, Gary Kohanbash, Wilson Barry Edwards, Eric Henderson, Jane Skjøth-Rasmussen, Ryan Orosco, Summer Gibbs, Richard W. Farnam, Lalitha Shankar, Baran Sumer, Anand T. N. Kumar, Laura Marcu, Lei Li, Viktor Greuv, Edward J. Delikatny, John Y. K. Lee, Sunil Singhal

JBO, Vol. 28, Issue 05, 050901, (May 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.5.050901

KEYWORDS: Tumors, Surgery, Dyes, Clinical trials, Cancer, Resection, Fluorescence, Cancer detection, Near infrared, Tissues

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Proceedings Article | 17 March 2023 Presentation

Demonstration of a combined multispectral FLIm/ polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions.

Julien Bec, Xiangnan Zhou, Pelham Keahey, Martin Villiger, Brett Bouma, Laura Marcu

Proceedings Volume PC12355, PC1235505 (2023) https://doi.org/10.1117/12.2649672

KEYWORDS: Optical coherence tomography, Polarization, Multispectral imaging, Imaging systems, Imaging devices, Visualization, Tissues, Reflectivity, Pathogens, Optical fibers

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Proceedings Article | 17 March 2023 Presentation

Anatomy-specific classification models using FLIm for head & neck cancer surgical guidance

Mohamed Hassan, Brent Weyers, Julien Bec, Andrew Birkeland, Arnaud Bewley, Marianne Abouyared, Laura Marcu, Farzad Fereidouni, Jinyi Qi, Dorina Gui, D. Gregory Farwell

Proceedings Volume 12354, 123540D (2023) https://doi.org/10.1117/12.2651235

KEYWORDS: Tumor growth modeling, Neck, Head, Cancer, Tongue, Tissues, Surgery, Physiology, Oncology, Lymphatic system

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Proceedings Article | 6 March 2023 Presentation

Photon economy of pulse-sampling vs TCSPC fluorescence lifetime imaging

Xiangnan Zhou, Julien Bec, Laura Marcu

Proceedings Volume PC12370, PC1237005 (2023) https://doi.org/10.1117/12.2650311

KEYWORDS: Fluorescence lifetime imaging, Sensors, Photodetectors, Luminescence, In vivo imaging, Tissues, Surgery, Pulsed laser operation, Photonic nanostructures, Laser systems engineering

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Proceedings Article | 6 March 2023 Presentation + Paper

Intraoperative detection of IDH-mutant glioma subtype using fluorescence lifetime imaging

Silvia Noble Anbunesan, Alba Alfonso-Garcia, Xiangnan Zhou, Julien Bec, Matthew Bobinski, Han Sung Lee, Lee-way Jin, Orin Bloch, Laura Marcu

Proceedings Volume 12368, 1236803 (2023) https://doi.org/10.1117/12.2650379

KEYWORDS: Tumors, Tissues, Resection, White matter, Fluorescence, Fluorescence lifetime imaging, Surgery, Medicine, Brain tissue, Brain

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SPIE Journal Paper | 16 February 2023 Open Access

Multimodal fluorescence lifetime imaging and optical coherence tomography for longitudinal monitoring of tissue-engineered cartilage maturation in a preclinical implantation model

Xiangnan Zhou, Anne Haudenschild, Cai Li, Laura Marcu

JBO, Vol. 28, Issue 02, 026003, (February 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.2.026003

KEYWORDS: Tissues, Optical coherence tomography, Cartilage, Biological samples, In vivo imaging, Fluorescence, Quantum channels, In vitro testing, Fluorescence lifetime imaging, Nondestructive evaluation

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SignificanceCartilage tissue engineering is a promising strategy for effective curative therapies for treatment of osteoarthritis. However, tissue engineers depend predominantly on time-consuming, expensive, and destructive techniques as quality control to monitor the maturation of engineered cartilage. This practice can be impractical for large-scale biomanufacturing and prevents spatial and temporal monitoring of tissue growth, which is critical for the fabrication of clinically relevant-sized cartilage constructs. Nondestructive multimodal imaging techniques combining fluorescence lifetime imaging (FLIm) and optical coherence tomography (OCT) hold great potential to address this challenge.AimThe feasibility of using multimodal FLIm–OCT for nondestructive, spatial, and temporal monitoring of self-assembled cartilage tissue maturation in a preclinical mouse model is investigated.ApproachSelf-assembled cartilage constructs were developed for 4 weeks in vitro followed by 4 weeks of in vivo maturation in nude mice. Sterile and nondestructive in situ multispectral FLIm and OCT imaging were carried out at multiple time points (t = 2, 4, and 8 weeks) during tissue development. FLIm and 3D volumetric OCT images were reconstructed and used for the analysis of tissue biochemical homogeneity, morphology, and structural integrity. A biochemical homogeneity index was computed to characterize nonhomogeneous tissue growth at different time points. OCT images were validated against histology.ResultsFLIm detects heterogenous extracellular matrix (ECM) growth of tissue-engineered cartilage. The outer edge of the tissue construct exhibited longer fluorescence lifetime in 375 to 410 and 450 to 485 nm spectral channels, indicating increase in collagen content. Significant (p < 0.05) decrease of construct homogeneity index was observed between t = 2 weeks and t = 4 weeks. Both FLIm and OCT images revealed defects (voids) at the center of the tissue construct during in vitro culture (t = 2 and 4 weeks). Cyst formation during in vivo culture was detected by OCT and confirmed with histology.ConclusionsThe ability of multimodal FLIm–OCT to nondestructively monitor the heterogenous growth of engineered tissue constructs in situ is demonstrated. Spatial and temporal variation of construct ECM component was detected by FLIm. OCT reveals structural defects (voids and cysts). This multimodal approach has great potential to replace costly destructive tests in the manufacturing of tissue-engineered medical products, facilitating their clinical translation.

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Proceedings Article | 11 January 2023 Presentation

Label-free imaging of collagen biomechanics

Benjamin Sherlock, Anne Haudenschild, Clay Sheaff, Jerry Hu, Xiangnan Zhou, J. Kent Leach, Laura Marcu, Kyriacos Athanasiou

Proceedings Volume 12333, 123330C (2023) https://doi.org/10.1117/12.2657927

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SPIE Journal Paper | 21 July 2022 Open Access

Dual-modality fluorescence lifetime imaging-optical coherence tomography intravascular catheter system with freeform catheter optics

Cai Li, Julien Bec, Xiangnan Zhou, Laura Marcu

JBO, Vol. 27, Issue 07, 076005, (July 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.7.076005

KEYWORDS: Optical coherence tomography, Luminescence, Ultraviolet radiation, Freeform optics, Infrared imaging, Imaging systems, Collimators, Tomography, Arteries, UV optics

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Proceedings Article | 9 March 2022 Presentation

Investigating sources of FLIm data variability in head & neck cancer

Mohamed Hassan, Sukhkaran Aulakh, Brent Weyers, Julien Bec, Athena Tam, Dorina Gui, Andrew Birkeland, Arnaud Bewley, Marianne Abouyared, D. Gregory Farwell, Laura Marcu

Proceedings Volume PC11949, PC1194902 (2022) https://doi.org/10.1117/12.2609864

KEYWORDS: Tissues, Cancer, Medical imaging, In vivo imaging, Statistical analysis, Machine learning, Tumors, Tongue, Patents, Neck

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Proceedings Article | 9 March 2022 Presentation

Real-time interrogation of brain tumors using intraoperative FLIm

Silvia Noble Anbunesan, Alba Alfonso García, Xiangnan Zhou, Julien Bec, Roberto Frusciante, Lisanne Kraft, Brent Weyers, Matthew Bobinski, Han Sung Lee, Lee-Way Jin, Orin Bloch, Laura Marcu

Proceedings Volume PC11949, PC1194904 (2022) https://doi.org/10.1117/12.2610424

KEYWORDS: Tumors, Brain, Tissues, Neuroimaging, Luminescence, Surgery, Statistical analysis, Pulsed laser operation, Proteins, Laser tissue interaction

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Proceedings Article | 7 March 2022 Presentation

Evaluation of a high-performance FLIm/OCT catheter system for biochemical and structural evaluation of atherosclerosis

Julien Bec, Cai Li, Xiangnan Zhou, Deborah Vela, Laura Marcu

Proceedings Volume PC11936, PC1193604 (2022) https://doi.org/10.1117/12.2607844

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Proceedings Article | 7 March 2022 Presentation

Real-time intraoperative fluorescence lifetime imaging of 5-ALA induced PpIX and autofluorescence in brain tumors: first results in patients

Xiangnan Zhou, Silvia Anbunesan, Alba Alfonso García, Julien Bec, Lisanne Kraft, Roberto Frusciante, Orin Bloch, Laura Marcu

Proceedings Volume PC11943, PC1194305 (2022) https://doi.org/10.1117/12.2612597

KEYWORDS: Tumors, Brain, Luminescence, Fluorescence lifetime imaging, Neuroimaging, Visualization, Tissues, Surgery, Video, System identification

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Proceedings Article | 5 March 2022 Presentation + Paper

Optimizing the light penetration depth in APDs and SPADs for high gain-bandwidth and ultra-wide spectral response

Cesar Bartolo-Perez, Ahmed Sulaiman Mayet, Soroush Ghandiparsi, Gerard Ariño-Estrada, Xiangnan Zhou, Julien Bec, Laura Marcu, Shih-Yuan Wang, M. Saif Islam, Ahasan Ahamed

Proceedings Volume 12009, 1200905 (2022) https://doi.org/10.1117/12.2610526

KEYWORDS: Avalanche photodetectors, Nanostructures, Absorption, Silicon, Photonic nanostructures, Sensors, Nanostructuring, Fluorescence lifetime imaging, Modulation, Avalanche photodiodes

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SPIE Journal Paper | 2 February 2022 Open Access

First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence

Alba Alfonso García, Xiangnan Zhou, Julien Bec, Silvia Anbunesan, Farzad Fereidouni, Lee-Way Jin, Han Sung Lee, Orin Bloch, Laura Marcu

JBO, Vol. 27, Issue 02, 020501, (February 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.2.020501

KEYWORDS: Luminescence, Tumors, Tissues, Brain, Microscopes, In vivo imaging, Surgery, Video, Data acquisition, Visualization

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Significance: 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is currently used for image-guided glioma resection. Typically, this widefield imaging method highlights the bulk of high-grade gliomas, but it underperforms at the infiltrating edge where PpIX fluorescence is not visible to the eyes. Fluorescence lifetime imaging (FLIm) has the potential to detect PpIX fluorescence below the visible detection threshold. Moreover, simultaneous acquisition of time-resolved nicotinamide adenine (phosphate) dinucleotide [NAD(P)H] fluorescence may provide metabolic information from the tumor environment to further improve overall tumor detection. Aim: We investigate the ability of pulse sampling, fiber-based FLIm to simultaneously image PpIX and NAD(P)H fluorescence of glioma infiltrative margins in patients. Approach: A mesoscopic fiber-based point-scanning FLIm device (355 nm pulses) was used to simultaneously resolve the fluorescence decay of PpIX (629/53 nm) and NAD(P)H (470/28 nm). The FLIm device enabled data acquisition at room light and rapid (<33 ms) augmentation of FLIm parameters on the surgical field-of-view. FLIm measurements from superficial tumors and tissue areas around the resection margins were performed on three glioblastoma patients in vivo following inspection of PpIX visible fluorescence with a conventional neurosurgical microscope. Microbiopsies were collected from FLIm imaged areas for histopathological evaluation. Results: The average lifetime from PpIX and NAD(P)H fluorescence distinguished between tumor and surrounding tissue. FLIm measurements of resection margins presented a range of PpIX and NAD(P)H lifetime values (τPpIX   ∼ 3 to 14 ns, τNAD(P)H = 3 to 6 ns) associated with unaffected tissue and areas of low-density tumor infiltration. Conclusions: Intraoperative FLIm could simultaneously detect the emission of PpIX and NAD(P)H from patients in vivo during craniotomy procedures. This approach doubles as a clinical tool to identify tumor areas while performing tissue resection and as a research tool to study tumor microenvironmental changes in vivo. Intraoperative FLIm of 5-ALA-induced PpIX and tissue autofluorescence makes a promising surgical adjunct to guide tumor resection surgery.

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Proceedings Article | 3 August 2021 Paper

Controlling light penetration depth to amplify the gain in ultra-fast silicon APDs and SPADs using photon-trapping nanostructures

Cesar Bartolo-Perez, Ahmed Sulaiman Mayet, Soroush GhandiParsi, Xiangnan Zhou, Julien Bec, Ahasan Ahamed, Gerard Ariño-Estrada, Ekaterina P. Devine, Shih-Yuan Wang, Laura Marcu, M. Saif Islam, Nibir K. Dhar

Proceedings Volume 11800, 118000F (2021) https://doi.org/10.1117/12.2597835

KEYWORDS: Absorption, Silicon, Avalanche photodetectors, Photonic nanostructures, Nanostructures, Avalanche photodiodes, Etching, Photonic devices, Photodiodes, Sensors

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Proceedings Article | 5 March 2021 Presentation

Label-free fluorescence lifetime techniques for image-guided surgery

Laura Marcu

Proceedings Volume 11656, 116560Z (2021) https://doi.org/10.1117/12.2583253

KEYWORDS: Luminescence, Tissues, Image-guided intervention, Imaging spectroscopy, Tissue optics, Spectroscopes, Robotic surgery, In vivo imaging, Fluorescence spectroscopy, Cancer

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Proceedings Article | 5 March 2021 Presentation

Head and neck cancer visualization using deep learning combined with fluorescence lifetime imaging and white light imaging

Takanori Fukazawa, Mark Marsden, Brent Weyers, Yu-Cheng Deng, Julien Bec, D. Gregory Farwell, Laura Marcu

Proceedings Volume 11631, 116310O (2021) https://doi.org/10.1117/12.2581449

KEYWORDS: Tumors, Visualization, Fluorescence lifetime imaging, Cancer, Algorithm development, Tissues, Surgery, Sensor fusion, Pathology, Optical sensors

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Proceedings Article | 5 March 2021 Presentation

Label-free assessment of biochemical markers of atherosclerotic plaque progression using intravascular fluorescence lifetime

Julien Bec, Deborah vela, L. Maximilian Buja, Kenneth Margulies, Laura Marcu

Proceedings Volume 11621, 116210N (2021) https://doi.org/10.1117/12.2579155

KEYWORDS: Luminescence, Ultraviolet radiation, Tissues, Spectroscopy, Optical coherence tomography, Multispectral imaging, Intravascular ultrasound, Imaging systems, Imaging spectroscopy, Foam

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Proceedings Article | 5 March 2021 Presentation

Multispectral fluorescence lifetime imaging system with Si avalanche photodetector: a better platform for clinical application

Xiangnan Zhou, Julien Bec, Diego Yankelevich, Laura Marcu

Proceedings Volume 11631, 116310E (2021) https://doi.org/10.1117/12.2579121

KEYWORDS: Imaging systems, Multispectral imaging, Fluorescence lifetime imaging, Avalanche photodetectors, Silicon, Tissues, Luminescence, Ultraviolet radiation, Tumors

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Proceedings Article | 5 March 2021 Presentation

High performance FLIm/OCT catheter system compatible for biochemical/structural evaluation of atherosclerosis

Cai Li, Julien Bec, Xiangnan Zhou, Laura Marcu

Proceedings Volume 11621, 116210P (2021) https://doi.org/10.1117/12.2577322

KEYWORDS: Optical coherence tomography, Solid state electronics, Integrated optics, Collimators, Tissues, Spectroscopy, Sensors, Microchannel plates, Light emitting diodes

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Proceedings Article | 5 March 2021 Presentation

Stereo reconstruction and 3D rendering for intraoperative fluorescence lifetime imaging visualization

Tianchen Sun, Julien Bec, Mark Marsden, Jakob Unger, Kwan-Liu Ma, Laura Marcu

Proceedings Volume 11631, 116310X (2021) https://doi.org/10.1117/12.2579009

KEYWORDS: Visualization, Fluorescence lifetime imaging, 3D visualizations, Surgery, 3D modeling, Reconstruction algorithms, Clouds, Tumors, Tissues, Robotics

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Proceedings Article | 5 March 2021 Presentation

Intraoperative FLIm for pathology detection and surgical guidance in oral and oropharyngeal cancer patients

Roberto Frusciante, Dorina Gui, Regina Gandour-Edwards, Brent Weyers, Mark Marsden, Takanori Fukazawa, Julien Bec, Andrew Birkeland, Arnaud Bewley, Marianne Abouyared, D. Gregory Farwell, Laura Marcu, John Hanks, Athena Tam

Proceedings Volume 11631, 116310V (2021) https://doi.org/10.1117/12.2576804

KEYWORDS: Cancer, Tumors, Pathology, Tissues, Luminescence, Tongue, Surgery, In vivo imaging, Imaging devices, Fluorescence lifetime imaging

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Proceedings Article | 5 March 2021 Presentation

Assessment of murine gut dysbiosis with intraluminal fluorescence lifetime imaging

Alba Alfonso García, Jee-Yon Lee, Cai Li, Julien Bec, Andreas Bäumler, Laura Marcu, Stephanie Cevallos

Proceedings Volume 11626, 116260I (2021) https://doi.org/10.1117/12.2578687

KEYWORDS: Tissues, Fluorescence lifetime imaging, Colon, Mode conditioning cables, Luminescence, Switches, Sodium, Inflammation, In vivo imaging, Diagnostics

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Proceedings Article | 5 March 2021 Presentation + Paper

Intraoperative margin assessment in head and neck cancer using label-free fluorescence lifetime imaging, machine learning and visualization

Brent Weyers, Takanori Fukazawa, Julien Bec, Tianchen Sun, Regina Gandour-Edwards, Andrew Birkeland, Arnaud Bewley, Marianne Abouyared, D. Gregory Farwell, Laura Marcu, Dorina Gui, Mark Marsden

Proceedings Volume 11631, 116310N (2021) https://doi.org/10.1117/12.2577051

KEYWORDS: Cancer, Visualization, Machine learning, Neck, Head, Fluorescence lifetime imaging, Tissues, Tongue, Tissue optics, Signal to noise ratio

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Proceedings Article | 9 March 2020 Presentation

Fiber-based instrument for simultaneous exogenous fluorescence and endogenous fluorescence lifetime imaging of engineered vascular tissue (Conference Presentation)

Cai Li, Alba Alfonso García, Lauren Uyesaka, Benjamin Sherlock, Leigh Griffiths, Laura Marcu

Proceedings Volume 11243, 1124313 (2020) https://doi.org/10.1117/12.2545251

KEYWORDS: Luminescence, Tissues, Imaging systems, Fluorescence lifetime imaging, Microscopy, Visualization, Optical imaging, Tissue optics, Multiplexing, Reflectivity

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Proceedings Article | 9 March 2020 Presentation

Fluorescence Lifetime Imaging (FLIm) for intraoperative pathology detection in transoral robotic surgery (Conference Presentation)

Brent Weyers, Mark Marsden, Tianchen Sun, Julien Bec, Arnaud Bewley, Regina Gandour-Edwards, Michael Moore, D. Gregory Farwell, Laura Marcu

Proceedings Volume 11229, 1122902 (2020) https://doi.org/10.1117/12.2545150

KEYWORDS: Tissues, Pathology, Fluorescence lifetime imaging, Robotic surgery, Cancer, Tumors, Surgery, Visualization, Endoscopy, Robotics

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Proceedings Article | 9 March 2020 Presentation

Novel broadband freeform micro-optics for multimodal FLIm-OCT intravascular catheter (Conference Presentation)

Cai Li, Laura Marcu, Julien Bec

Proceedings Volume 11215, 112150H (2020) https://doi.org/10.1117/12.2544488

KEYWORDS: Micro optics, Optical coherence tomography, UV optics, GRIN lenses, Near ultraviolet, Optics manufacturing, Fluorescence lifetime imaging, Tissues, Chromatic aberrations, Reflectivity

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Proceedings Article | 9 March 2020 Presentation

Augmented reality visualization for intraoperative guidance and tumor delineation based on fluorescence lifetime (Conference Presentation)

Tianchen Sun, Jakob Unger, Richard Bold, Morgan Darrow, Kwan-Liu Ma, Laura Marcu

Proceedings Volume 11229, 1122903 (2020) https://doi.org/10.1117/12.2547125

KEYWORDS: Visualization, Augmented reality, Tumors, Luminescence, Tissues, Surgery, Information visualization, Data acquisition, Real time imaging, Navigation systems

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Proceedings Article | 9 March 2020 Presentation

Visualization and quantification of biochemical markers of atherosclerotic plaque progression using intravascular fluorescence lifetime (Conference Presentation)

Julien Bec, Deborah Vela, Jennifer Phipps, Michael Agung, Jakob Unger, Ken Margulies, Maximilian Buja, Laura Marcu

Proceedings Volume 11215, 112150E (2020) https://doi.org/10.1117/12.2546921

KEYWORDS: Luminescence, Microsoft Foundation Class Library, Visualization, Intravascular ultrasound, Arteries, Imaging systems, In vivo imaging, Fluorescence lifetime imaging, Tissues, Biological research

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Proceedings Article | 9 March 2020 Presentation

FLIm guided Raman imaging for detecting bovine pericardium cross-links and calcification (Conference Presentation)

Xiangnan Zhou, Anne Haudenschild, Alba Alfonso Garcia, Christoph Krafft, Laura Marcu, Jürgen Popp, Tanveer Ahmed Shaik

Proceedings Volume 11215, 112150I (2020) https://doi.org/10.1117/12.2545632

KEYWORDS: Raman spectroscopy, Fluorescence lifetime imaging, Analog electronics, Target acquisition, Data acquisition, Luminescence, Tissues, Nondestructive evaluation

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Proceedings Article | 9 March 2020 Presentation

FLIm and Raman imaging for detecting micro-environmental changes in bovine pericardium upon genipin cross-linking (Conference Presentation)

Tanveer Ahmed Shaik, Anne Haudenschild, Alba Alfonso García, Christoph Krafft, Laura Marcu, Jürgen Popp, James Mcmasters, Florian Korinth, Martin Richter

Proceedings Volume 11243, 112431B (2020) https://doi.org/10.1117/12.2544225

KEYWORDS: Raman spectroscopy, Fluorescence lifetime imaging, In vitro testing, Analog electronics, Target acquisition, Data acquisition, Luminescence, Tissues, Nondestructive evaluation

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Proceedings Article | 7 March 2019 Presentation

Fluorescence lifetime imaging and intravascular ultrasound (FLIm/IVUS) platform for label-free intraluminal characterization of vascular biomaterials in vitro and in vivo (Conference Presentation)

Alba Alfonso García, Anne Haudenschild, James Mcmasters, Julien Bec, Xiangnan Zhou, Alyssa Panitch, Leigh Griffiths, Laura Marcu

Proceedings Volume 10855, 1085509 (2019) https://doi.org/10.1117/12.2510816

KEYWORDS: In vivo imaging, In vitro testing, Fluorescence lifetime imaging, Arteries, Tissues, Intravascular ultrasound, Structured optical fibers, Multispectral imaging, Imaging systems, Natural surfaces

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Proceedings Article | 7 March 2019 Presentation

Real-time delineation of cancer margins in otolaryngologic applications using multispectral FLIm (Conference Presentation)

Brent Weyers, Tianchen Sun, Jakob Unger, Hanna Kim, Julien Bec, Michael Moore, Arnaud Bewley, Gregory Farwell, Laura Marcu

Proceedings Volume 10868, 108680L (2019) https://doi.org/10.1117/12.2506795

KEYWORDS: Cancer, Tissues, Tumors, Pathology, Fiber optics, Time resolved spectroscopy, In vivo imaging, Tongue

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Proceedings Article | 7 March 2019 Presentation

Study of vascular tissue grafts cellularization process in bioreactors using label-free fluorescence lifetime imaging (Conference Presentation)

Cai Li, James Mcmasters, Alba Alfonso García, Julien Bec, Anne Haudenschild, Alyssa Panitch, Leigh Griffiths, Laura Marcu

Proceedings Volume 10855, 108550A (2019) https://doi.org/10.1117/12.2510823

KEYWORDS: Tissues, Fluorescence lifetime imaging, Nondestructive evaluation, Control systems, Manufacturing, Multispectral imaging, Stem cells, Prototyping

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Proceedings Article | 4 March 2019 Presentation

Multimodal evaluation of tissue engineered cartilage maturation in a pre-clinical implantation model (Conference Presentation)

Anne Haudenschild, Xiangnan Zhou, Cai Li, Jerry Hu, J. Kent Leach, Kyriacos Athanasiou, Laura Marcu

Proceedings Volume 10876, 108760A (2019) https://doi.org/10.1117/12.2509047

KEYWORDS: Tissues, Cartilage, Optical coherence tomography, Nondestructive evaluation, Tissue optics, Optics manufacturing, Imaging systems, Fluorescence lifetime imaging, Fiber optics, Interfaces

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SPIE Journal Paper | 21 December 2018 Open Access

Detection of glycosaminoglycan loss in articular cartilage by fluorescence lifetime imaging

Xiangnan Zhou, Anne Haudenschild, Benjamin Sherlock, Jerry Hu, J. Kent Leach, Kyriacos Athanasiou, Laura Marcu

JBO, Vol. 23, Issue 12, 126002, (December 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.12.126002

KEYWORDS: Cartilage, Luminescence, Collagen, Fluorescence lifetime imaging, Tissues, Image segmentation, Statistical analysis, Imaging spectroscopy, In vivo imaging, Signal detection

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Proceedings Article | 5 April 2018 Presentation

Multichannel solid state photodetection system for low-cost fluorescence lifetime spectroscopy (Conference Presentation)

Diego Yankelevich, Julien Bec, Jonathan Wapman, Laura Marcu

Proceedings Volume 10484, 104840H (2018) https://doi.org/10.1117/12.2291180

KEYWORDS: Luminescence, Photodetectors, Fluorescence spectroscopy, Spectroscopy, Solid state physics, Capacitors, Laser beam diagnostics, Microchannel plates, Optical fibers, Tissues

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Proceedings Article | 14 March 2018 Presentation

Study of bovine pericardium biochemical and biomechanical properties during collagenase degradation using fluorescence lifetime imaging (Conference Presentation)

Jeny Shklover, Mojtaba Parvizi, Benjamin Sherlock, Alba Alfonso García, Leigh Griffiths, Laura Marcu, Cai Li

Proceedings Volume 10471, 1047103 (2018) https://doi.org/10.1117/12.2287487

KEYWORDS: Collagen, Fluorescence lifetime imaging, In vivo imaging, Luminescence, Proteins, Molecules, Tissue engineering, Nondestructive evaluation, In vitro testing, Imaging systems

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Proceedings Article | 14 March 2018 Presentation

Real-time visualization of tumor margins in breast specimen using fluorescence lifetime (Conference Presentation)

Jakob Unger, Christoph Hebisch, Jennifer Phipps, Richard Bold, Morgan Darrow, Laura Marcu

Proceedings Volume 10472, 104720H (2018) https://doi.org/10.1117/12.2289619

KEYWORDS: Tumors, Luminescence, Cancer, Visualization, Breast cancer, Surgery, Breast, Machine learning, Video, Lead

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Proceedings Article | 14 March 2018 Presentation

Tracking recellularization processes in vascular tissues with fiber-based autofluorescence lifetime imaging (Conference Presentation)

Leigh Griffiths, Laura Marcu, Alba Alfonso García, Jeny Shklover, Benjamin Sherlock, James Mcmasters, Alyssa Panitch

Proceedings Volume 10471, 1047106 (2018) https://doi.org/10.1117/12.2288821

KEYWORDS: Tissues, Luminescence, In vivo imaging, Fluorescence lifetime imaging, Natural surfaces, Imaging systems, Nondestructive evaluation, Fiber optics, Interfaces, Stem cells

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SPIE Journal Paper | 6 March 2018 Open Access

Nondestructive assessment of collagen hydrogel cross-linking using time-resolved autofluorescence imaging

Benjamin Sherlock, Jenna Harvestine, Debika Mitra, Anne Haudenschild, Jerry Hu, Kyriacos A. Athanasiou, J. Kent Leach, Laura Marcu

JBO, Vol. 23, Issue 03, 036004, (March 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.3.036004

KEYWORDS: Collagen, Luminescence, Nondestructive evaluation, Tissues, Tissue engineering, Statistical analysis, Auto-fluorescence imaging, Imaging systems, Regenerative medicine, Point spread functions

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SPIE Journal Paper | 2 January 2018 Open Access

Method for accurate registration of tissue autofluorescence imaging data with corresponding histology: a means for enhanced tumor margin assessment

Jakob Unger, Tianchen Sun, Yi-Ling Chen, Jennifer Phipps, Richard Bold, Morgan Darrow, Kwan-Liu Ma, Laura Marcu

JBO, Vol. 23, Issue 01, 015001, (January 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.1.015001

KEYWORDS: Image registration, Tissues, Tissue optics, Auto-fluorescence imaging, Tumors, Luminescence, Diagnostics, Laser marking, Video, Image segmentation

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SPIE Journal Paper | 29 December 2017 Open Access

Label-free optical imaging technologies for rapid translation and use during intraoperative surgical and tumor margin assessment

Stephen A. Boppart, J. Quincy Brown, Camile S. Farah, Esther Kho, Laura Marcu, Christobel M. Saunders, Henricus J. C. M. Sterenborg

JBO, Vol. 23, Issue 02, 021104, (December 2017) https://doi.org/10.1117/12.10.1117/1.JBO.23.2.021104

KEYWORDS: Tumors, Tissues, Optical imaging, Surgery, Tissue optics, In vivo imaging, Biomedical optics, Pathology, Natural surfaces, Cancer

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SPIE Journal Paper | 23 December 2017 Open Access

Biophotonics: the big picture

Laura Marcu, Stephen A. Boppart, Mark Hutchinson, Jürgen Popp, Brian Wilson

JBO, Vol. 23, Issue 02, 021103, (December 2017) https://doi.org/10.1117/12.10.1117/1.JBO.23.2.021103

KEYWORDS: Biomedical optics, Medicine, Imaging systems, Photonics, Image processing, Biology, Optical imaging, Visualization, Interference (communication), Signal detection

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Proceedings Article | 24 April 2017 Presentation

A strategy to measure electrophysiological changes with photoacoustic imaging (Conference Presentation)

Rebecka Sepela, Benjamin Sherlock, Laura Marcu, Jon Sack, Lin Tian

Proceedings Volume 10064, 100642C (2017) https://doi.org/10.1117/12.2251050

KEYWORDS: Environmental sensing, Absorption, Photoacoustic imaging, Ion channels, Photoacoustic spectroscopy, Proteins, Brain, Neuroimaging, Structural imaging

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Proceedings Article | 19 April 2017 Presentation

Fluorescence lifetime technique for surgical imaging, guidance and augmented reality (Conference Presentation)

Laura Marcu

Proceedings Volume 10049, 1004909 (2017) https://doi.org/10.1117/12.2257039

KEYWORDS: Tumors, Surgery, In vivo imaging, Multispectral imaging, Tissues, Luminescence, Cancer, Pathology, Augmented reality, Instrumentation engineering

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Proceedings Article | 19 April 2017 Presentation

Breast cancer margin delineation with fluorescence lifetime imaging (Conference Presentation)

Jennifer Phipps, Dimitris Gorpas, Morgan Darrow, Jakob Unger, Richard Bold, Laura Marcu

Proceedings Volume 10043, 100430C (2017) https://doi.org/10.1117/12.2253211

KEYWORDS: Tumors, Imaging systems, Tissues, Breast cancer, Fluorescence lifetime imaging, Cancer, Breast, Luminescence, Surgery, Collagen

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Proceedings Article | 19 April 2017 Presentation

Fluorescence lifetime intravascular ultrasound (FLIm-IVUS) and the quest to discriminate between early and advanced lipid cores in atherosclerosis (Conference Presentation)

Jennifer Phipps, Julien Bec, Deborah Vela, L. Maximilian Buja, Kenneth Margulies, Jeffrey Southard, Laura Marcu

Proceedings Volume 10042, 100420C (2017) https://doi.org/10.1117/12.2253185

KEYWORDS: Imaging systems, Heart, Intravascular ultrasound, Luminescence, Fluorescence lifetime imaging, Arteries, Foam, Ultrasonography, Calcium, Diagnostics and therapeutics

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Proceedings Article | 19 April 2017 Presentation

Autofluorescence lifetime imaging during transoral robotic surgery: a clinical validation study of tumor detection (Conference Presentation)

João Lagarto, Jennifer Phipps, Jakob Unger, Leta Faller, Dimitris Gorpas, Dinglong Ma, Julien Bec, Michael Moore, Arnaud Bewley, Diego Yankelevich, Jonathan Sorger, Gregory Farwell, Laura Marcu

Proceedings Volume 10039, 100390E (2017) https://doi.org/10.1117/12.2253226

KEYWORDS: Tumors, Imaging systems, Biological detection systems, Tissues, In vivo imaging, Robotic surgery, Fiber optics, Surgery, Spectroscopes, Fiber optics tests

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Proceedings Article | 19 April 2017 Presentation

Prostate cancer diagnosis with fluorescence lifetime imaging (Conference Presentation)

Shamira Sridharan, Regina Gandour-Edwards, Marc Dall'Era, Laura Marcu

Proceedings Volume 10038, 1003803 (2017) https://doi.org/10.1117/12.2253233

KEYWORDS: Prostate cancer, Luminescence, Biopsy, Prostate, Tissues, Diagnostics, Algorithm development, Fluorescence lifetime imaging, Time resolved spectroscopy, Fiber optics

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Proceedings Article | 19 April 2017 Presentation

Detection of radiation-induced brain necrosis in live rats using label-free time-resolved fluorescence spectroscopy (TRFS) (Conference Presentation)

Brad Hartl, Laura Marcu, Ruben Fragoso, Katherine Hansen, Htet S. Ma, Melanie Klich, Shamira Sridharan, Michael Kent, Kyoungmi Kim, Julian Perks

Proceedings Volume 10054, 100540H (2017) https://doi.org/10.1117/12.2253735

KEYWORDS: Tumors, Tissue optics, Tissues, Brain, Luminescence, Surgery, Time resolved spectroscopy, Biopsy, Animal model studies, Magnetic resonance imaging

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Proceedings Article | 19 April 2017 Presentation

Three-dimensional online surface reconstruction of augmented fluorescence lifetime maps using photometric stereo (Conference Presentation)

Jakob Unger, Joao Lagarto, Jennifer Phipps, Dinglong Ma, Julien Bec, Jonathan Sorger, Gregory Farwell, Richard Bold, Laura Marcu

Proceedings Volume 10054, 100540F (2017) https://doi.org/10.1117/12.2253229

KEYWORDS: Luminescence, Natural surfaces, Tissue optics, Image segmentation, Tissues, Time resolved spectroscopy, Raster graphics, 3D modeling, Cameras, Pathology

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Proceedings Article | 27 April 2016 Presentation

Support vector machine based classification and mapping of atherosclerotic plaques using fluorescence lifetime imaging (Conference Presentation)

Hussain Fatakdawala, Dimitris Gorpas, Julien Bec, Dinglong Ma, Diego Yankelevich, Laura Marcu, John Bishop

Proceedings Volume 9689, 968934 (2016) https://doi.org/10.1117/12.2214028

KEYWORDS: Fluorescence lifetime imaging, Data modeling, Data acquisition, Classification systems, Tissues, Clinical research, Animal model studies, Library classification systems, Diagnostics, Current controlled current source

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Proceedings Article | 27 April 2016 Presentation

Combined fiber probe for fluorescence lifetime and Raman spectroscopy (Conference Presentation)

Sebastian Dochow, Dinglong Ma, Ines Latka, Thomas Bocklitz, Brad Hartl, Julien Bec, Hussain Fatakdawala, Sebastian Wachsmann-Hogiu, Eric Marple, Kirk Urmey, Michael Schmitt, Laura Marcu, Jürgen Popp

Proceedings Volume 9698, 969806 (2016) https://doi.org/10.1117/12.2214151

KEYWORDS: Raman spectroscopy, Luminescence, In vivo imaging, Tissues, Biomedical optics, Raster graphics, Diagnostics, Biological research, Spectroscopy, Fiber optics

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Proceedings Article | 26 April 2016 Presentation

Activation of photodynamic therapy in vitro with Cerenkov luminescence generated from Yttrium-90 (Conference Presentation)

Brad Hartl, Henry Hirschberg, Laura Marcu, Simon Cherry

Proceedings Volume 9694, 96940B (2016) https://doi.org/10.1117/12.2213920

KEYWORDS: Luminescence, Photodynamic therapy, In vitro testing, Tumors, Tissues, Breast, In vivo imaging, Tumor growth modeling, Current controlled current source

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Proceedings Article | 13 April 2016 Presentation + Paper

Online multispectral fluorescence lifetime values estimation and overlay onto tissue white-light video frames

Dimitris Gorpas, Dinglong Ma, Julien Bec, Diego Yankelevich, Laura Marcu

Proceedings Volume 9696, 969609 (2016) https://doi.org/10.1117/12.2213895

KEYWORDS: Luminescence, Tissues, Image segmentation, Video, Fluorescence lifetime imaging, Augmented reality, Real time imaging, Data acquisition, RGB color model, Tissue optics, Time resolved spectroscopy, Cameras, Raster graphics

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Proceedings Article | 12 March 2015 Paper

Fluorescence lifetime spectroscopy for breast cancer margins assessment

Dimitris Gorpas, Hussain Fatakdawala, Yanhong Zhang, Richard Bold, Laura Marcu

Proceedings Volume 9318, 93180B (2015) https://doi.org/10.1117/12.2079622

KEYWORDS: Tissues, Fourier transforms, Luminescence, Breast cancer, Surgery, Breast, Collagen, Fluorescence spectroscopy, Spectroscopy, Tumors

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Proceedings Article | 26 February 2015 Paper

Multimodal imaging of vascular grafts using time-resolved fluorescence and ultrasound

Hussain Fatakdawala, Leigh Griffiths, Laura Marcu, Maelene Wong, Matheau Julien

Proceedings Volume 9303, 930335 (2015) https://doi.org/10.1117/12.2078278

KEYWORDS: Tissues, Luminescence, Ultrasonography, Time resolved spectroscopy, In vivo imaging, Arteries, Transducers, Nondestructive evaluation, Multimodal imaging, Collagen

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Proceedings Article | 26 February 2015 Paper

In-vivo validation of fluorescence lifetime imaging (FLIm) of coronary arteries in swine

Julien Bec, Dinglong Ma, Diego Yankelevich, Dimitris Gorpas, William Ferrier, Jeffrey Southard, Laura Marcu

Proceedings Volume 9303, 93033M (2015) https://doi.org/10.1117/12.2079833

KEYWORDS: In vivo imaging, Imaging systems, Luminescence, Data acquisition, Arteries, Francium, Fluorescence lifetime imaging, Optical fibers, Blood, Fluorescent markers

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SPIE Journal Paper | 22 August 2014 Open Access

Time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy for nondestructive evaluation of vascular grafts

Hussain Fatakdawala, Leigh Griffiths, Sterling Humphrey, Laura Marcu

JBO, Vol. 19, Issue 08, 080503, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.080503

KEYWORDS: Tissues, Collagen, Backscatter, Luminescence, Nondestructive evaluation, Time resolved spectroscopy, Ultrasonography, In vivo imaging, Visualization, Microscopy

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SPIE Journal Paper | 4 June 2014 Open Access

Rotational multispectral fluorescence lifetime imaging and intravascular ultrasound: bimodal system for intravascular applications

Dinglong Ma, Julien Bec, Diego Yankelevich, Dimitris Gorpas, Hussain Fatakdawala, Laura Marcu

JBO, Vol. 19, Issue 06, 066004, (June 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.6.066004

KEYWORDS: Intravascular ultrasound, Luminescence, Imaging systems, Arteries, Data acquisition, Signal to noise ratio, Multispectral imaging, Fiber optics, Fluorescence lifetime imaging, Transducers

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Proceedings Article | 20 March 2014 Paper

Ultra-low fluence rate photodynamic therapy: simulation of light emitted by the Cerenkov effect

Jonathan Gonzales, Fred Wang, Anthony Trinidad, Genesis Zamora, Henry Hirschberg, Laura Marcu, Simon Cherry

Proceedings Volume 8928, 89280F (2014) https://doi.org/10.1117/12.2041631

KEYWORDS: Photodynamic therapy, Tumors, Light, Visible radiation, Cerenkov radiation imaging, Tissue optics, Absorption, Phototherapy, Diagnostics and therapeutics, Radioisotopes

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Proceedings Article | 4 March 2014 Paper

Bi-modal imaging of atherosclerotic plaques: Automated method for co-registration between fluorescence lifetime imaging and intravascular ultrasound data

John Bishop, Dimitris Gorpas, Hussain Fatakdawala, Julien Bec, Dinglong Ma, Diego Yankelevich, Jinyi Qi, Laura Marcu

Proceedings Volume 8926, 892638 (2014) https://doi.org/10.1117/12.2040311

KEYWORDS: Intravascular ultrasound, Image segmentation, Luminescence, Image processing, Data acquisition, Fluorescence lifetime imaging, Image restoration, Image registration, Image filtering, Arteries

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SPIE Journal Paper | 1 November 2012 Open Access

In vivo validation of a bimodal technique combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy for diagnosis of oral carcinoma

Yang Sun, Hongtao Xie, Jing Liu, Matthew Lam, Abhijit Chaudhari, Feifei Zhou, Julien Bec, Diego Yankelevich, Allison Dobbie, Steven Tinling, Regina Gandour-Edwards, Wayne Monsky, Gregory Farwell, Laura Marcu

JBO, Vol. 17, Issue 11, 116003, (November 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.11.116003

KEYWORDS: Tissues, Luminescence, Tumors, Collagen, In vivo imaging, Time resolved spectroscopy, Ultrasonics, Ultrasonography, Tissue optics, Transducers

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SPIE Journal Paper | 1 October 2012 Open Access

Design, construction, and validation of a rotary multifunctional intravascular diagnostic catheter combining multispectral fluorescence lifetime imaging and intravascular ultrasound

Julien Bec, Hongtao Xie, Diego Yankelevich, Feifei Zhou, Yang Sun, Narugopal Ghata, Ralph Aldredge, Laura Marcu

JBO, Vol. 17, Issue 10, 106012, (October 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.10.106012

KEYWORDS: Intravascular ultrasound, Luminescence, Blood, Fiber optics, Diagnostics, Arteries, Data acquisition, Transducers, Tissues, Imaging systems

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SPIE Journal Paper | 1 September 2011 Open Access

Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaques

Jennifer Phipps, Yinghua Sun, Nisa Hatami, Laura Marcu, Ramez Saroufeem, Michael Fishbein

JBO, Vol. 16, Issue 09, 096018, (September 2011) https://doi.org/10.1117/12.10.1117/1.3626865

KEYWORDS: Fluorescence lifetime imaging, Luminescence, Lawrencium, Chromium, Collagen, Tissues, Deconvolution, Arteries, Microscopy, Image segmentation

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Proceedings Article | 18 February 2011 Paper

Towards development of an intravascular diagnostic catheter based on fluorescence lifetime spectroscopy: study of an optimized blood flushing system

Laura Marcu, Ralph Aldredge, Narugopal Ghata, Julien Bec

Proceedings Volume 7883, 78833E (2011) https://doi.org/10.1117/12.874957

KEYWORDS: Blood circulation, Blood, Blood vessels, Luminescence, Fluorescence spectroscopy, Spectroscopy, Turbulence, Diagnostics, 3D modeling, Pathology

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Proceedings Article | 18 February 2011 Paper

Design, construction, and validation of a multimodal intravascular diagnostic catheter combining IVUS and fluorescence lifetime spectroscopy detection channels

Julien Bec, Ralph Aldredge, Yang Sun, Narugopal Ghata, Diego Yankelevich, Laura Marcu, Hongtao Xie, Feifei Zhou

Proceedings Volume 7883, 788337 (2011) https://doi.org/10.1117/12.875095

KEYWORDS: Intravascular ultrasound, Luminescence, Blood, Fiber optics, Fluorescence spectroscopy, Transducers, Diagnostics, Francium, Data acquisition, Time resolved spectroscopy

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SPIE Journal Paper | 1 September 2010 Open Access

Fluorescence lifetime imaging microscopy for brain tumor image-guided surgery

Yinghua Sun, Nisa Hatami, Matthew Yee, Jennifer Phipps, Daniel Elson, Fredric Gorin, Rudolph Schrot, Laura Marcu

JBO, Vol. 15, Issue 05, 056022, (September 2010) https://doi.org/10.1117/12.10.1117/1.3486612

KEYWORDS: Tumors, Luminescence, Fluorescence lifetime imaging, Brain, Tissues, Neuroimaging, Microscopy, Image-guided intervention, Endoscopy, Natural surfaces

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Proceedings Article | 3 March 2010 Paper

Endoscopic fluorescence lifetime imaging microscopy (FLIM) images of aortic plaque: an automated classification method

Amit Rajaram, Jennifer Phipps, Michael Fishbein, Ramez Saroufeem, Nisa Hatami, Laura Marcu, Yinghua Sun

Proceedings Volume 7548, 754839 (2010) https://doi.org/10.1117/12.842724

KEYWORDS: Fluorescence lifetime imaging, Image classification, Collagen, Luminescence, Microscopy, Deconvolution, Endoscopy, Diagnostics, Image processing, Algorithm development

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SPIE Journal Paper | 1 March 2010 Open Access

Intraoperative delineation of primary brain tumors using time-resolved fluorescence spectroscopy

Pramod Butte, Fang Qiyin, Jo Javier, William Yong, Brian Pikul, Keith Black, Laura Marcu

JBO, Vol. 15, Issue 02, 027008, (March 2010) https://doi.org/10.1117/12.10.1117/1.3374049

KEYWORDS: Luminescence, Brain, Tumors, Tissues, Tissue optics, In vivo imaging, Surgery, Spectroscopy, Fluorescence spectroscopy, Biopsy

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SPIE Journal Paper | 1 January 2010 Open Access

Fluorescence lifetime in cardiovascular diagnostics

Laura Marcu

JBO, Vol. 15, Issue 01, 011106, (January 2010) https://doi.org/10.1117/12.10.1117/1.3327279

KEYWORDS: Luminescence, Fluorescence lifetime imaging, Tissues, Time resolved spectroscopy, Intravascular ultrasound, Diagnostics, Fluorescence spectroscopy, Arteries, Spectroscopy, Imaging spectroscopy

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SPIE Journal Paper | 1 May 2009 Open Access

Intraluminal fluorescence spectroscopy catheter with ultrasound guidance

Douglas Stephens, Jesung Park, Yang Sun, Thanassis Papaioannou, Laura Marcu

JBO, Vol. 14, Issue 03, 030505, (May 2009) https://doi.org/10.1117/12.10.1117/1.3146813

KEYWORDS: Intravascular ultrasound, Blood, Optical fibers, Arteries, Prototyping, Luminescence, Fluorescence spectroscopy, Ultrasonography, Tissue optics, In vitro testing

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Proceedings Article | 23 February 2009 Paper

Fluorescence lifetime imaging microscopy for the characterization of atherosclerotic plaques

Ramez Saroufeem, Laura Marcu, Yinghua Sun, Jennifer Phipps, Nisa Hatami

Proceedings Volume 7161, 71612G (2009) https://doi.org/10.1117/12.813087

KEYWORDS: Fluorescence lifetime imaging, Luminescence, Collagen, Microscopy, Image processing, Endoscopy, Deconvolution, Temporal resolution, Picosecond phenomena, Optical filters

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Proceedings Article | 21 February 2008 Paper

Novel tissue phantom for testing a dual-modality diagnostic system: time-resolved fluorescence spectroscopy and high frequency ultrasound

Jesung Park, Yinghua Sun, Laura Marcu, Yang Sun, Kuo-Chih Liao

Proceedings Volume 6870, 68700D (2008) https://doi.org/10.1117/12.764013

KEYWORDS: Optical fibers, Ultrasonography, Tissue optics, Luminescence, Tissues, Spectroscopy, Polymers, Ultrasonics, Diagnostics, Fluorescence spectroscopy

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SPIE Journal Paper | 1 July 2007 Open Access

Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis

Jingjing Wang, William Yong, Yinghua Sun, P. Thomas Vernier, H. Phillip Koeffler, Martin Gundersen, Laura Marcu

JBO, Vol. 12, Issue 04, 044021, (July 2007) https://doi.org/10.1117/12.10.1117/1.2764463

KEYWORDS: Tumors, Brain, Tissues, Luminescence, Quantum dots, Neuroimaging, Receptors, Tissue optics, Nanoparticles, In vivo imaging

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SPIE Journal Paper | 1 March 2006 Open Access

Laguerre-based method for analysis of time-resolved fluorescence data: application to in-vivo characterization and diagnosis of atherosclerotic lesions

Javier Jo, Qiyin Fang, Thanassis Papaioannou, J. Dennis Baker, Amir Dorafshar, Todd Reil, Jianhua Qiao, Michael Fishbein, Julie Freischlag, Laura Marcu

JBO, Vol. 11, Issue 02, 021004, (March 2006) https://doi.org/10.1117/12.10.1117/1.2186045

KEYWORDS: Time resolved spectroscopy, Luminescence, Statistical analysis, Principal component analysis, Tissues, Surface plasmons, In vivo imaging, Deconvolution, Biological research, Spectroscopy

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SPIE Journal Paper | 1 March 2006 Open Access

Fluorescence microscopy imaging of electroperturbation in mammalian cells

Yinghua Sun, P. Thomas Vernier, Matthew Behrend, Jingjing Wang, Mya Mya Thu, Martin Gundersen, Laura Marcu

JBO, Vol. 11, Issue 02, 024010, (March 2006) https://doi.org/10.1117/12.10.1117/1.2187970

KEYWORDS: Luminescence, Calcium, Microscopy, Imaging systems, Picosecond phenomena, Fermium, Frequency modulation, Microscopes, Electrodes, Computing systems

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SPIE Journal Paper | 1 March 2006 Open Access

Special Section Guest Editorial: Cardiovascular Photonics

Laura Marcu, Guillermo Tearney, Kenton Gregory

JBO, Vol. 11, Issue 02, 021001, (March 2006) https://doi.org/10.1117/12.10.1117/1.2191508

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Proceedings Article | 25 February 2006 Paper

Packaging and characteristics of a microfluorescence spectroscopy analyzer

Q. Fang, M. Gundersen, Q. Shui, T. Papaioannou, J. Lo, E. Kim, L. Marcu, W. Pang

Proceedings Volume 6080, 60800H (2006) https://doi.org/10.1117/12.649297

KEYWORDS: Packaging, Microelectromechanical systems, Sensors, Silicon, Mirrors, Spectroscopy, Diffraction gratings, Semiconducting wafers, Monochromators, Actuators

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Proceedings Article | 22 February 2006 Paper

Detection of high-risk atherosclerotic lesions by time-resolved fluorescence spectroscopy based on the Laguerre deconvolution technique

M. Fishbein, Jianhua Qiao, T. Reil, Qiyin Fang, J. Freischlag, A. Dorafshar, D. Baker, L. Marcu, B. Beseth, Javier Jo, Thanassis Papaioannou

Proceedings Volume 6078, 60782H (2006) https://doi.org/10.1117/12.647560

KEYWORDS: Luminescence, Deconvolution, Tissues, Spectroscopy, Laser induced fluorescence, Inflammation, Fluorescence spectroscopy, Time resolved spectroscopy, Data analysis, In vivo imaging

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Proceedings Article | 15 February 2006 Paper

Design and fabrication of a disposable percutaneous glucose sensor

William Clifton, Kuo-Chih Liao, Frances Richmond, Laura Marcu, Gerald Loeb, Thieo Hogen-Esch

Proceedings Volume 6083, 60830V (2006) https://doi.org/10.1117/12.643990

KEYWORDS: Glucose, Sensors, Optical fibers, Luminescence, Polymers, Chemical analysis, In vivo imaging, Collagen, Ultraviolet radiation, Chemical fiber sensors

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SPIE Journal Paper | 1 November 2005 Open Access

Diagnosis of meningioma by time-resolved fluorescence spectroscopy

Pramod Butte, Brian Pikul, Aviv Hever, William Yong, Keith Black, Laura Marcu

JBO, Vol. 10, Issue 06, 064026, (November 2005) https://doi.org/10.1117/12.10.1117/1.2141624

KEYWORDS: Luminescence, Tissues, Tumors, Tissue optics, Time resolved spectroscopy, Fluorescence spectroscopy, Brain, Spectroscopy, Collagen, Diagnostics

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Proceedings Article | 1 April 2005 Paper

Piezoelectric optical MEMS scanning fluorescence biosensor

Martin Gundersen, Laura Marcu, Joe Lo, Eun Kim

Proceedings Volume 5692, (2005) https://doi.org/10.1117/12.591386

KEYWORDS: Diffraction gratings, Microelectromechanical systems, Sensors, Aluminum, Zinc oxide, Diffraction, Luminescence, Spectral resolution, Actuators, Electrodes

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Proceedings Article | 31 March 2005 Paper

A fluorescence microscopy study of quantum dots as fluorescent probes for brain tumor diagnosis

P. Thomas Vernier, Laura Marcu, Martin Gundersen, Jingjing Wang, Yinghua Sun

Proceedings Volume 5703, (2005) https://doi.org/10.1117/12.591385

KEYWORDS: Tumors, Brain, Luminescence, Quantum dots, Microscopy, Imaging spectroscopy, Neuroimaging, Tissues, Biomedical optics, Receptors

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Proceedings Article | 29 March 2005 Paper

Picosecond fluorescence lifetime imaging microscope for imaging of living glioma cells

Thanassis Papaioannou, Jingjing Wang, Mya Thu, Qiyin Fang, Laura Marcu, Yinghua Sun, Martin Gundersen, Thomas Vernier, Javier Jo

Proceedings Volume 5699, (2005) https://doi.org/10.1117/12.592474

KEYWORDS: Luminescence, Fluorescence lifetime imaging, Microscopes, Picosecond phenomena, Semiconductor lasers, Microscopy, Imaging systems, Rhodamine, Cameras, Optical filters

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Proceedings Article | 23 March 2005 Paper

Design and fabrication of disposable percutaneous chemical sensors

Kuo-Chih Liao, Frances Richmond, Thieo Hogen-Esch, Laura Marcu, Gerald Loeb

Proceedings Volume 5691, (2005) https://doi.org/10.1117/12.587668

KEYWORDS: Glucose, Sensors, Luminescence, Fluorescence resonance energy transfer, Chemical analysis, Optical fibers, In vivo imaging, Polymers, Blood, Filtering (signal processing)

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Proceedings Article | 13 July 2004 Paper

Validation of a time-resolved fluorescence spectroscopy apparatus in a rabbit atherosclerosis model

Todd Reil, Thanassis Papaioannou, Laura Marcu, Jian-Hua Qiao, Javier Jo, Julie Freischlag, Qiyin Fang, Michael Fishbein, Amir Dorafshar

Proceedings Volume 5312, (2004) https://doi.org/10.1117/12.529677

KEYWORDS: Luminescence, Time resolved spectroscopy, In vivo imaging, Fiber optics, Foam, Fluorescence spectroscopy, Data acquisition, Tissues, Signal to noise ratio, Spectroscopes

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Proceedings Article | 13 July 2004 Paper

Laguerre nonparametric deconvolution technique of time-resolved fluorescence data: application to the prediction of concentrations in a mixture of biochemical components

Qiyin Fang, Laura Marcu, Thanasis Papaioannou, Javier Jo

Proceedings Volume 5326, (2004) https://doi.org/10.1117/12.527787

KEYWORDS: Luminescence, Deconvolution, Data modeling, Time resolved spectroscopy, Biological research, Error analysis, Pulsed laser operation, Solids, Statistical modeling, Rhodamine B

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SPIE Journal Paper | 1 July 2004 Open Access

Fast model-free deconvolution of fluorescence decay for analysis of biological systems

Javier Jo, Qiyin Fang, Thanassis Papaioannou, Laura Marcu

JBO, Vol. 9, Issue 04, (July 2004) https://doi.org/10.1117/12.10.1117/1.1752919

KEYWORDS: Luminescence, Deconvolution, Data modeling, Biological research, Time resolved spectroscopy, Tissues, Complex systems, Pulsed laser operation, Solids, Bioalcohols

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Proceedings Article | 8 October 2003 Paper

Lifetime fluorescence apparatus for clinical investigations of tissues

Thanassis Papaioannou, Russel Vaitha, Laura Marcu, Javier Jo, Kumar Shastry, Qiyin Fang

Proceedings Volume 5141, (2003) https://doi.org/10.1117/12.501020

KEYWORDS: Luminescence, Tissues, Fiber optics, Time resolved spectroscopy, Deconvolution, In vivo imaging, Fluorescence spectroscopy, Light sources, Spectroscopes, Diagnostics

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Proceedings Article | 8 October 2003 Paper

Fluorescence microscopy studies of a peripheral-benzodiazepine-receptor-targeted molecular probe for brain tumor imaging

P. Thomas Vernier, Darryl Bornhop, Martin Gundersen, Aimin Li, H. Charles Manning, Laura Marcu, Sarah Salemi, Cheryl Craft

Proceedings Volume 5141, (2003) https://doi.org/10.1117/12.501033

KEYWORDS: Luminescence, Tumors, Brain, Microscopy, Neuroimaging, Lanthanides, Ions, Digital image correlation, Receptors, Europium

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Proceedings Article | 27 August 2003 Paper

Lifetime fluorescence spectroscopy for in situ investigation of osteogenic differentiation

Peter Ashjian, Hamza Kurt, Daniel De Ugarte, Marc Hedrick, Laura Marcu, Patricia Zuk, Prosper Benhaim, Amir Elbarbary

Proceedings Volume 4961, (2003) https://doi.org/10.1117/12.477913

KEYWORDS: Collagen, Luminescence, Tissues, Time resolved spectroscopy, Fluorescence spectroscopy, Spectroscopy, Skin, Statistical analysis, Bone, Laser induced fluorescence

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Proceedings Article | 29 July 2003 Paper

Estimation of optical fluorescent impulse response kernel in combined time and wavelength spaces

Olga Ivanova, Laura Marcu, Michael Khoo

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478213

KEYWORDS: Luminescence, Tissues, Data modeling, System identification, Bioalcohols, Signal processing, Statistical analysis, Statistical modeling, Interference (communication), Pulsed laser operation

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Proceedings Article | 29 July 2003 Paper

Effects of tissue optical properties on time-resolved fluorescence measurements from brain tumors: an experimental and computational study

Laura Marcu, Brian Pikul, Karthik Vishwanath, Pramod Butte, Mary-Ann Mycek

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478192

KEYWORDS: Brain, Tissue optics, Scattering, Tissues, Luminescence, Reflectivity, Laser scattering, Tumors, Diffusion, Optical properties

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Proceedings Article | 22 July 2003 Paper

Performance evaluation of fiber optic probes for tissue lifetime fluorescence spectroscopy

Russel Ross, Hamza Kurt, Qiyin Fang, Linda Jones, Michael Carnohan, Greg Cottone, Laura Marcu, Thanassis Papaioannou, Norris Preyer, Adam Brightwell

Proceedings Volume 4958, (2003) https://doi.org/10.1117/12.476141

KEYWORDS: Monte Carlo methods, Fiber optics, Tissues, Tissue optics, Fluorescence spectroscopy, Photons, Diagnostics, Diffuse reflectance spectroscopy, Biomedical optics, Spectroscopy

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Proceedings Article | 22 July 2003 Paper

Compact time-resolved laser-induced fluorescence spectroscopic system for clinical investigations of diseased tissues

Russel Vaitha, Laura Marcu, Thanassis Papaioannou, Kumar Shastry, Qiyin Fang, Javier Jo

Proceedings Volume 4958, (2003) https://doi.org/10.1117/12.476133

KEYWORDS: Luminescence, Time resolved spectroscopy, Laser induced fluorescence, Data acquisition, Spectrographs, Fluorescence spectroscopy, Fiber optics, Calibration, Signal to noise ratio, Pulsed laser operation

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Proceedings Article | 1 May 2002 Paper

Time-resolved fluorescence spectroscopy of human brain tumors

Laura Marcu, Smita Garde, William Yong, Reid Thompson, Keith Black, Mark Sedrak

Proceedings Volume 4613, (2002) https://doi.org/10.1117/12.465244

KEYWORDS: Brain, Tumors, Luminescence, Tissues, Time resolved spectroscopy, Laser induced fluorescence, Fluorescence spectroscopy, Spectroscopy, Monochromators, Laser spectroscopy

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Proceedings Article | 1 May 2002 Paper

Detection of experimental brain tumors using time-resolved laser-induced fluorescence spectroscopy

Reid Thompson, Laura Marcu, Keith Black, Babak Kateb

Proceedings Volume 4613, (2002) https://doi.org/10.1117/12.465236

KEYWORDS: Tumors, Brain, Luminescence, Tissues, Fluorescence spectroscopy, Time resolved spectroscopy, Spectroscopy, Laser induced fluorescence, Laser spectroscopy, In vivo imaging

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Proceedings Article | 21 May 2001 Paper

Arterial fluorescent components involved in atherosclerotic plaque instability: differentiation by time-resolved fluorescence spectroscopy

Jean-Michel Maarek, Laura Marcu, Warren Grundfest

Proceedings Volume 4244, (2001) https://doi.org/10.1117/12.427829

KEYWORDS: Collagen, Luminescence, Proteins, Time resolved spectroscopy, Laser induced fluorescence, Spectroscopy, Fluorescence spectroscopy, Tissues, Nitrogen lasers, Foam

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Proceedings Article | 19 April 2000 Paper

Characterization of type I, II, III, IV, and V collagens by time-resolved laser-induced fluorescence spectroscopy

David Cohen, Jean-Michel Maarek, Warren Grundfest, Laura Marcu

Proceedings Volume 3917, (2000) https://doi.org/10.1117/12.382720

KEYWORDS: Collagen, Luminescence, Tissues, Laser induced fluorescence, Skin, Time resolved spectroscopy, Fluorescence spectroscopy, Laser spectroscopy, Cartilage, Spectroscopy

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Proceedings Article | 19 April 2000 Paper

Global analysis of arterial fluorescence decay spectra

Laura Marcu, Jean-Michel Maarek, Warren Grundfest

Proceedings Volume 3917, (2000) https://doi.org/10.1117/12.382722

KEYWORDS: Luminescence, Tissues, Signal to noise ratio, Statistical modeling, Statistical analysis, Time resolved spectroscopy, Arteries, Pulsed laser operation, Deconvolution, Nitrogen lasers

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Proceedings Article | 2 July 1999 Paper

Classification of aortic atherosclerotic lesions with time-resolved fluorescence spectroscopy

Michael Fishbein, Jean-Michel Maarek, Laura Marcu, Warren Grundfest

Proceedings Volume 3600, (1999) https://doi.org/10.1117/12.351030

KEYWORDS: Luminescence, Time resolved spectroscopy, Statistical analysis, Pulsed laser operation, Fluorescence spectroscopy, Statistical modeling, Monochromators, Nitrogen lasers, Continuous wave operation

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Proceedings Article | 2 July 1999 Paper

Time-resolved laser-induced fluorescence of normal and atherosclerotic coronary artery

Michael Fishbein, Laura Marcu, Warren Grundfest, Jean-Michel Maarek

Proceedings Volume 3600, (1999) https://doi.org/10.1117/12.351029

KEYWORDS: Luminescence, Arteries, Tissues, Laser induced fluorescence, Oscilloscopes, Spectroscopy, Collagen, Fluorescence spectroscopy, Time resolved spectroscopy, Monochromators

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Proceedings Article | 16 April 1998 Paper

Time-resolved laser-induced fluorescence of lipids involved in development of atherosclerotic lesion lipid-rich core

Warren Grundfest, Laura Marcu, Jean-Michel Maarek

Proceedings Volume 3250, (1998) https://doi.org/10.1117/12.305375

KEYWORDS: Luminescence, Laser induced fluorescence, Oscilloscopes, Monochromators, Photomultipliers, Pulsed laser operation, Nitrogen lasers, Sensors, Carbon monoxide, Fluorescence spectroscopy

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Proceedings Article | 16 April 1998 Paper

Characterization of atherosclerotic lesions with laser-induced time-resolved fluorescence spectroscopy

Warren Grundfest, Laura Marcu, Jean-Michel Maarek

Proceedings Volume 3250, (1998) https://doi.org/10.1117/12.305377

KEYWORDS: Luminescence, Time resolved spectroscopy, Pulsed laser operation, Tissues, Collagen, Statistical analysis, Monochromators, Laser applications, Nitrogen lasers, Inspection

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Proceedings Article | 12 April 1995 Paper

Skeletal muscle hemoglobin content measured by near-infrared spectroscopy during oscillatory venous pressure variation

Sandra Howell, Laura Marcu, Atul Bembi, Jean-Michel Maarek

Proceedings Volume 2387, (1995) https://doi.org/10.1117/12.206825

KEYWORDS: Mercury, Near infrared spectroscopy, Tissue optics, Signal processing, Blood, Optical signal processing, Tissues, Spectroscopy, Semiconductor lasers, Near infrared

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Proceedings Article | 12 April 1995 Paper

Near-infrared monitoring of hemoglobin content in the kidney during ischemia

Wendy Snyder, Jean-Michel Maarek, Thanassis Papaioannou, Laura Marcu, Sandor Vari, Vani Pergadia, Warren Grundfest

Proceedings Volume 2387, (1995) https://doi.org/10.1117/12.206827

KEYWORDS: Kidney, Ischemia, Blood, Near infrared spectroscopy, Blood circulation, Blood pressure, Semiconductor lasers, Surgery, Tissues, Photomultipliers

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Proceedings Article | 19 May 1994 Paper

Near-infrared monitoring of perfusion and oxygen availability in abdominal organs and skeletal muscle during hypoxia

Laura Marcu, Wendy Snyder, Warren Grundfest, Sandor Vari, Vani Pergadia, Thanassis Papaioannou, Jean-Michel Maarek

Proceedings Volume 2135, (1994) https://doi.org/10.1117/12.175989

KEYWORDS: Kidney, Hypoxia, Liver, Blood, Tissues, Oxygen, Near infrared spectroscopy, Near infrared, Optical fibers, Spectroscopy

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Showing 5 of 116 publications

Proceedings Volume Editor (17)

SPIE Conference Volume | 22 March 2024

Diagnostic and Therapeutic Applications of Light in Cardiology 2024

SPIE Conference Volume | 14 April 2023

Diagnostic and Therapeutic Applications of Light in Cardiology 2023

SPIE Conference Volume | 28 March 2022

Diagnostic and Therapeutic Applications of Light in Cardiology 2022

SPIE Conference Volume | 23 April 2021

Diagnostic and Therapeutic Applications of Light in Cardiology 2021

SPIE Conference Volume | 11 March 2020

Diagnostic and Therapeutic Applications of Light in Cardiology 2020

Showing 5 of 17 publications

Conference Committee Involvement (30)

Diagnostic and Therapeutic Applications of Light in Cardiology 2025

25 January 2025 | San Francisco, California, United States

Diagnostic and Therapeutic Applications of Light in Cardiology 2024

27 January 2024 | San Francisco, California, United States

Diagnostic and Therapeutic Applications of Light in Cardiology 2023

28 January 2023 | San Francisco, California, United States

Diagnostic and Therapeutic Applications of Light in Cardiology 2022

22 January 2022 | San Francisco, California, United States

Diagnostic and Therapeutic Applications of Light in Cardiology 2021

6 March 2021 | Online Only, California, United States

Diagnostic and Therapeutic Applications of Light in Cardiology 2020

1 February 2020 | San Francisco, California, United States

Diagnostic and Therapeutic Applications of Light in Cardiology 2019

2 February 2019 | San Francisco, California, United States

Diagnostic and Therapeutic Applications of Light in Cardiology 2018

27 January 2018 | San Francisco, California, United States