Polarization interference mapping of microscopic images of protein fluorofores in the differential diagnosis of benign and malignant prostate tumours

L. Trifonyuk; A. Strashkevich; N. Pavlyukovich; A. Pavlyukovich; Yu. Tomka; V. Zhytaryuk; V. I. Tkachuk

doi:10.1117/12.2616836

20 December 2021 Polarization interference mapping of microscopic images of protein fluorofores in the differential diagnosis of benign and malignant prostate tumours

L. Trifonyuk, A. Strashkevich, N. Pavlyukovich, A. Pavlyukovich, Yu. Tomka, V. Zhytaryuk, V. I. Tkachuk

Author Affiliations +

Proceedings Volume 12126, Fifteenth International Conference on Correlation Optics; 1212628 (2021) https://doi.org/10.1117/12.2616836
Event: Fifteenth International Conference on Correlation Optics, 2021, Chernivtsi, Ukraine

Abstract

The paper presents the results of the possibility of a polarization-interference approach to the analysis of microscopic images of biological preparations in the differential diagnosis [1-7] of benign and malignant prostate tumors with different degrees of differentiation. Measurements and analysis of maps and histograms of the distribution of the local contrast value of polarization-interference distributions of microscopic images of biological preparations of the prostate. Determination of the relationship between the statistical moments of the 1st - 4th orders, characterizing the distributions of the value of the local contrast of polarization-interference distributions of microscopic images of biological preparations of the prostate [8-12]. Determination of statistical criteria for polarization-interference diagnosis of histological sections of biopsy of adenoma and adenocarcinoma of the prostate with varying degrees of differentiation. Determination of operational characteristics (sensitivity, specificity, accuracy) of the diagnostic power [13-19] of the polarization interferometry method for differential diagnosis of histological sections of biopsy of adenoma and adenocarcinoma of the prostate with varying degrees of differentiation.

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L. Trifonyuk, A. Strashkevich, N. Pavlyukovich, A. Pavlyukovich, Yu. Tomka, V. Zhytaryuk, and V. I. Tkachuk "Polarization interference mapping of microscopic images of protein fluorofores in the differential diagnosis of benign and malignant prostate tumours", Proc. SPIE 12126, Fifteenth International Conference on Correlation Optics, 1212628 (20 December 2021); https://doi.org/10.1117/12.2616836

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KEYWORDS

Prostate

Biopsy

Biological research

Statistical analysis

Polarization

Tumors

Proteins

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